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RPS8 ribosomal protein S8 [ Homo sapiens (human) ]

Gene ID: 6202, updated on 9-Feb-2020

Summary

Official Symbol
RPS8provided by HGNC
Official Full Name
ribosomal protein S8provided by HGNC
Primary source
HGNC:HGNC:10441
See related
Ensembl:ENSG00000142937 MIM:600357
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S8
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 2095.9), bone marrow (RPKM 913.3) and 25 other tissues See more
Orthologs

Genomic context

See RPS8 in Genome Data Viewer
Location:
1p34.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (44775540..44778779)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45241213..45244427)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U5D small nuclear 1 Neighboring gene kinesin family member 2C Neighboring gene small nucleolar RNA, C/D box 160 Neighboring gene small nucleolar RNA, C/D box 55 Neighboring gene small nucleolar RNA, C/D box 46 Neighboring gene small nucleolar RNA, C/D box 38A Neighboring gene small nucleolar RNA, C/D box 38B Neighboring gene ribosomal protein S15a pseudogene 11 Neighboring gene bestrophin 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S8 (RPS8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S8 (RPS8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S8 (RPS8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S8 (RPS8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation IC
Inferred by Curator
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit HDA PubMed 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
cytosolic small ribosomal subunit TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
40S ribosomal protein S8
Names
OK/SW-cl.83
small ribosomal subunit protein eS8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012.2NP_001003.1  40S ribosomal protein S8

    See identical proteins and their annotated locations for NP_001003.1

    Status: REVIEWED

    Source sequence(s)
    AL592166
    Consensus CDS
    CCDS513.1
    UniProtKB/Swiss-Prot
    P62241
    UniProtKB/TrEMBL
    Q5JR94
    Related
    ENSP00000379888.3, ENST00000396651.8
    Conserved Domains (1) summary
    PTZ00148
    Location:1206
    PTZ00148; 40S ribosomal protein S8; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    44775540..44778779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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