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RPS6KA2 ribosomal protein S6 kinase A2 [ Homo sapiens (human) ]

Gene ID: 6196, updated on 5-Sep-2021

Summary

Official Symbol
RPS6KA2provided by HGNC
Official Full Name
ribosomal protein S6 kinase A2provided by HGNC
Primary source
HGNC:HGNC:10431
See related
Ensembl:ENSG00000071242 MIM:601685
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSK; HU-2; RSK3; p90RSK2; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2
Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in thyroid (RPKM 23.1), lung (RPKM 22.2) and 24 other tissues See more
Orthologs
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Genomic context

See RPS6KA2 in Genome Data Viewer
Location:
6q27
Exon count:
26
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (166409364..166862525, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (166822852..167276013, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100289495 Neighboring gene mitochondrial pyruvate carrier 1 Neighboring gene RPS6KA2 intronic transcript 1 Neighboring gene microRNA 1913 Neighboring gene uncharacterized LOC107986671 Neighboring gene RNA guanine-7 methyltransferase activating subunit like (pseudogene) Neighboring gene insulin like growth factor 2 mRNA binding protein 3 pseudogene Neighboring gene RPS6KA2 antisense RNA 1 Neighboring gene protein GVQW1-like Neighboring gene ribonuclease T2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
GeneReviews: Not available
Genome-wide association scan of dental caries in the permanent dentition.
GeneReviews: Not available
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in brain renin-angiotensin system IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to carbohydrate stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
 
involved_in heart contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
involved_in oocyte maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein processing IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in meiotic spindle IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribosomal protein S6 kinase alpha-2
Names
MAP kinase-activated protein kinase 1c
MAPK-activated protein kinase 1c
mitogen-activated protein kinase-activated protein kinase 1C
ribosomal S6 kinase 3
ribosomal protein S6 kinase, 90kDa, polypeptide 2
NP_001006933.3
NP_001305865.2
NP_001305866.1
NP_001305867.1
NP_066958.2
XP_006715612.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006932.3NP_001006933.3  ribosomal protein S6 kinase alpha-2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1, and initiates translation at an alternate start codon. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AL022069, AL159163, Z98049
    Consensus CDS
    CCDS34570.1
    Related
    ENSP00000427015.1, ENST00000503859.5
    Conserved Domains (2) summary
    cd05582
    Location:71387
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14178
    Location:419711
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
  2. NM_001318936.2NP_001305865.2  ribosomal protein S6 kinase alpha-2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region compared to variant 1, and initiates translation at an alternate start codon. The encoded isoform (c) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AL022069, AL023775, AL159163, Z98049
    Consensus CDS
    CCDS83148.1
    Related
    ENSP00000422435.1, ENST00000510118.5
    Conserved Domains (2) summary
    cd05582
    Location:88404
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14178
    Location:436728
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
  3. NM_001318937.2NP_001305866.1  ribosomal protein S6 kinase alpha-2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region compared to variant 1, and initiates translation at an alternate start codon. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AB209116, AL022069, BQ029058, DA320139, KJ535080
    UniProtKB/Swiss-Prot
    Q15349
    UniProtKB/TrEMBL
    X5D337
    Conserved Domains (4) summary
    smart00220
    Location:1220
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14178
    Location:313605
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
    pfam00069
    Location:317574
    Pkinase; Protein kinase domain
    cl21453
    Location:3281
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001318938.1NP_001305867.1  ribosomal protein S6 kinase alpha-2 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region compared to variant 1, and initiates translation at a downstream start codon. The encoded isoform (e) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AB209116, AK295674, AL022069, BQ029058, DC402728, Z98049
    Consensus CDS
    CCDS83147.1
    UniProtKB/Swiss-Prot
    Q15349
    UniProtKB/TrEMBL
    B7Z3B5
    Related
    ENSP00000422484.1, ENST00000481261.6
    Conserved Domains (4) summary
    smart00220
    Location:1229
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:1290
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14178
    Location:322614
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
    pfam00069
    Location:326583
    Pkinase; Protein kinase domain
  5. NM_021135.6NP_066958.2  ribosomal protein S6 kinase alpha-2 isoform a

    See identical proteins and their annotated locations for NP_066958.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AB209116, AL022069, BC002363, BQ029058, HY150133
    Consensus CDS
    CCDS5294.1
    UniProtKB/Swiss-Prot
    Q15349
    Related
    ENSP00000265678.4, ENST00000265678.9
    Conserved Domains (4) summary
    smart00220
    Location:59318
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:63379
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14178
    Location:411703
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
    pfam00069
    Location:415672
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    166409364..166862525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715549.3XP_006715612.1  ribosomal protein S6 kinase alpha-2 isoform X1

    Conserved Domains (4) summary
    smart00220
    Location:87346
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:91407
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14178
    Location:439731
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
    pfam00069
    Location:443700
    Pkinase; Protein kinase domain
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