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Rps6ka2 ribosomal protein S6 kinase, polypeptide 2 [ Mus musculus (house mouse) ]

Gene ID: 20112, updated on 21-May-2024

Summary

Official Symbol
Rps6ka2provided by MGI
Official Full Name
ribosomal protein S6 kinase, polypeptide 2provided by MGI
Primary source
MGI:MGI:1342290
See related
Ensembl:ENSMUSG00000023809 AllianceGenome:MGI:1342290
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rsk3; 90kDa; p90rsk; pp90rsk; D17Wsu134e; Rps6ka-rs1
Summary
Enables ribosomal protein S6 kinase activity. Acts upstream of or within several processes, including cardiac muscle cell apoptotic process; oocyte maturation; and regulation of gene expression. Located in cytoplasm and meiotic spindle. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human RPS6KA2 (ribosomal protein S6 kinase A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 18.1), heart adult (RPKM 11.1) and 25 other tissues See more
Orthologs
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Genomic context

See Rps6ka2 in Genome Data Viewer
Location:
17 A1; 17 4.7 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (7356384..7570714)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (7088971..7303315)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2470 Neighboring gene STARR-seq mESC enhancer starr_41744 Neighboring gene ribonuclease T2B Neighboring gene predicted gene 1604b Neighboring gene predicted gene, 25119 Neighboring gene STARR-seq mESC enhancer starr_41745 Neighboring gene STARR-positive B cell enhancer mm9_chr17:7374004-7374305 Neighboring gene STARR-seq mESC enhancer starr_41746 Neighboring gene VISTA enhancer mm108 Neighboring gene STARR-seq mESC enhancer starr_41751 Neighboring gene G protein-coupled receptor 31, D17Leh66a region Neighboring gene t-complex protein 10a

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ribosomal protein S6 kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within brain renin-angiotensin system IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to carbohydrate stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within heart contraction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within heart development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of meiotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within oocyte maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribosomal protein S6 kinase alpha-2
Names
90 kDa ribosomal protein S6 kinase 2
MAP kinase-activated protein kinase 1c
MAPK-activated protein kinase 1c
MAPKAP kinase 1c
MAPKAPK-1c
RSK-3
S6K-alpha 2
p90-RSK 2
p90RSK2
pp90RSK3
protein-tyrosine kinase Mpk-9
ribosomal S6 kinase 3
ribosomal protein S6 kinase, 90kD, polypeptide 2
NP_035429.1
XP_006523261.1
XP_006523262.1
XP_006523263.1
XP_006523264.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011299.5NP_035429.1  ribosomal protein S6 kinase alpha-2

    See identical proteins and their annotated locations for NP_035429.1

    Status: VALIDATED

    Source sequence(s)
    AC117241, AC126433
    Consensus CDS
    CCDS28376.1
    UniProtKB/Swiss-Prot
    Q9D2C0, Q9WUT3
    UniProtKB/TrEMBL
    Q7TPD5
    Related
    ENSMUSP00000024575.7, ENSMUST00000024575.8
    Conserved Domains (2) summary
    cd05582
    Location:63379
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14178
    Location:411703
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    7356384..7570714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523199.4XP_006523262.1  ribosomal protein S6 kinase alpha-2 isoform X2

    UniProtKB/TrEMBL
    Q8CHM5
    Conserved Domains (2) summary
    cd05582
    Location:46362
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14178
    Location:394686
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
  2. XM_006523198.5XP_006523261.1  ribosomal protein S6 kinase alpha-2 isoform X1

    UniProtKB/TrEMBL
    Q8CHM5
    Related
    ENSMUSP00000159974.1, ENSMUST00000249877.1
    Conserved Domains (2) summary
    cd05582
    Location:47363
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14178
    Location:395687
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
  3. XM_006523201.2XP_006523264.1  ribosomal protein S6 kinase alpha-2 isoform X3

    See identical proteins and their annotated locations for XP_006523264.1

    UniProtKB/TrEMBL
    Q8CHM5
    Conserved Domains (2) summary
    cd14178
    Location:304596
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
    cl21453
    Location:1272
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006523200.2XP_006523263.1  ribosomal protein S6 kinase alpha-2 isoform X3

    See identical proteins and their annotated locations for XP_006523263.1

    UniProtKB/TrEMBL
    Q8CHM5
    Conserved Domains (2) summary
    cd14178
    Location:304596
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
    cl21453
    Location:1272
    PKc_like; Protein Kinases, catalytic domain