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RPS6KA1 ribosomal protein S6 kinase A1 [ Homo sapiens (human) ]

Gene ID: 6195, updated on 4-Jun-2020

Summary

Official Symbol
RPS6KA1provided by HGNC
Official Full Name
ribosomal protein S6 kinase A1provided by HGNC
Primary source
HGNC:HGNC:10430
See related
Ensembl:ENSG00000117676 MIM:601684
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSK; HU-1; RSK1; p90Rsk; MAPKAPK1; MAPKAPK1A
Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in small intestine (RPKM 31.6), duodenum (RPKM 29.3) and 21 other tissues See more
Orthologs

Genomic context

See RPS6KA1 in Genome Data Viewer
Location:
1p36.11
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (26529761..26575028)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26856249..26901520)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.3789 Neighboring gene developmental pluripotency associated 2 pseudogene 2 Neighboring gene microRNA 1976 Neighboring gene RNA, 7SL, cytoplasmic 679, pseudogene Neighboring gene uncharacterized LOC105376888

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ribosomal protein S6 kinase alpha-1
Names
90 kDa ribosomal protein S6 kinase 1
MAP kinase-activated protein kinase 1a
MAPK-activated protein kinase 1a
MAPKAP kinase 1a
MAPKAPK-1a
RSK-1
S6K-alpha 1
dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)
p90-RSK 1
p90RSK1
p90S6K
ribosomal S6 kinase 1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
NP_001006666.1
NP_001317370.1
NP_002944.2
XP_024304639.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006665.2NP_001006666.1  ribosomal protein S6 kinase alpha-1 isoform b

    See identical proteins and their annotated locations for NP_001006666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' end of the coding region compared to variant 1. These differences cause translation initiation at an in-frame AUG of an alternate exon and an isoform (b) with a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL627313
    Consensus CDS
    CCDS30649.1
    UniProtKB/Swiss-Prot
    Q15418
    Related
    ENSP00000435412.1, ENST00000531382.5
    Conserved Domains (4) summary
    smart00220
    Location:71329
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:75391
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:425715
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
    pfam00069
    Location:427684
    Pkinase; Protein kinase domain
  2. NM_001330441.2NP_001317370.1  ribosomal protein S6 kinase alpha-1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' end of the coding region compared to variant 1. These differences cause translation initiation at an in-frame AUG of an alternate exon and an isoform (c) with a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL627313
    Consensus CDS
    CCDS81286.1
    UniProtKB/Swiss-Prot
    Q15418
    Related
    ENSP00000432281.1, ENST00000530003.5
    Conserved Domains (2) summary
    cd05582
    Location:50366
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:400690
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
  3. NM_002953.4NP_002944.2  ribosomal protein S6 kinase alpha-1 isoform a

    See identical proteins and their annotated locations for NP_002944.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AL627313
    Consensus CDS
    CCDS284.1
    UniProtKB/Swiss-Prot
    Q15418
    Related
    ENSP00000363283.2, ENST00000374168.7
    Conserved Domains (2) summary
    cd05582
    Location:66382
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:416706
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    26529761..26575028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448871.1XP_024304639.1  ribosomal protein S6 kinase alpha-1 isoform X1

    Related
    ENSP00000431651.1, ENST00000526792.5
    Conserved Domains (2) summary
    cd05582
    Location:1290
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:324614
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_009646195.1 Reference GRCh38.p13 PATCHES

    Range
    17379..62643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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