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Rps6ka1 ribosomal protein S6 kinase polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 20111, updated on 8-May-2024

Summary

Official Symbol
Rps6ka1provided by MGI
Official Full Name
ribosomal protein S6 kinase polypeptide 1provided by MGI
Primary source
MGI:MGI:104558
See related
Ensembl:ENSMUSG00000003644 AllianceGenome:MGI:104558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rsk; Rsk1; Rsk-1; p90S6K; p90rsk; p90Rsk1; p90-Rsk1; Mapkapk-1a; S6K-alpha-1
Summary
Enables kinase activity. Involved in hepatocyte proliferation. Located in spindle. Is expressed in central nervous system; early conceptus; oocyte; and retina. Orthologous to human RPS6KA1 (ribosomal protein S6 kinase A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 79.7), colon adult (RPKM 69.8) and 24 other tissues See more
Orthologs
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Genomic context

See Rps6ka1 in Genome Data Viewer
Location:
4 D2.3; 4 66.37 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133574601..133615466, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133847290..133887797, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1284 Neighboring gene predicted gene, 34296 Neighboring gene STARR-seq mESC enhancer starr_11650 Neighboring gene predicted gene, 25270 Neighboring gene predicted gene 12974 Neighboring gene STARR-positive B cell enhancer ABC_E1285 Neighboring gene STARR-positive B cell enhancer ABC_E9599 Neighboring gene STARR-positive B cell enhancer ABC_E4677 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133434348-133434549 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133435172-133435325 Neighboring gene predicted gene 12977 Neighboring gene predicted gene, 22523 Neighboring gene STARR-seq mESC enhancer starr_11658 Neighboring gene STARR-seq mESC enhancer starr_11662 Neighboring gene STARR-positive B cell enhancer ABC_E6230 Neighboring gene high mobility group nucleosomal binding domain 2 Neighboring gene dehydrodolichyl diphosphate synthase Neighboring gene STARR-positive B cell enhancer ABC_E9085

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribosomal protein S6 kinase alpha-1
Names
90 kDa ribosomal protein S6 kinase 1
MAP kinase-activated protein kinase 1a
MAPK-activated protein kinase 1a
MAPKAP kinase 1a
ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1
NP_001272434.1
NP_001272435.1
NP_001365809.1
NP_033123.2
XP_036019817.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285505.1NP_001272434.1  ribosomal protein S6 kinase alpha-1 isoform b

    See identical proteins and their annotated locations for NP_001272434.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AL837508, BC049076, BY737295
    Consensus CDS
    CCDS71488.1
    UniProtKB/Swiss-Prot
    P18653
    UniProtKB/TrEMBL
    Q3UFZ5
    Related
    ENSMUSP00000003741.10, ENSMUST00000003741.16
    Conserved Domains (4) summary
    smart00220
    Location:62309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:66371
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:405695
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
    pfam00069
    Location:407664
    Pkinase; Protein kinase domain
  2. NM_001285506.1NP_001272435.1  ribosomal protein S6 kinase alpha-1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, and it initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    BC049076, BY226173, CA547794
    Consensus CDS
    CCDS71487.1
    UniProtKB/TrEMBL
    E9PWV3, Q3TIM6
    Related
    ENSMUSP00000126774.3, ENSMUST00000168974.9
    Conserved Domains (4) summary
    smart00220
    Location:46304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:50366
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:400690
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
    pfam00069
    Location:402659
    Pkinase; Protein kinase domain
  3. NM_001378880.1NP_001365809.1  ribosomal protein S6 kinase alpha-1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL837508
    UniProtKB/TrEMBL
    F6Q8A4, Q3TIM6
    Related
    ENSMUSP00000119328.3, ENSMUST00000137486.3
    Conserved Domains (2) summary
    cd05582
    Location:72388
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:422712
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
  4. NM_009097.5NP_033123.2  ribosomal protein S6 kinase alpha-1 isoform a

    See identical proteins and their annotated locations for NP_033123.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL837508, BC049076, BY737295
    Consensus CDS
    CCDS18758.2
    UniProtKB/TrEMBL
    Q3UFZ5, Q505N6
    Related
    ENSMUSP00000101514.5, ENSMUST00000105894.11
    Conserved Domains (2) summary
    cd05582
    Location:66382
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:416706
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    133574601..133615466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163924.1XP_036019817.1  ribosomal protein S6 kinase alpha-1 isoform X1

    UniProtKB/TrEMBL
    Q3UFZ5, Q505N6
    Conserved Domains (2) summary
    cd05582
    Location:66382
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:416706
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)