Format

Send to:

Choose Destination

RPS3A ribosomal protein S3A [ Homo sapiens (human) ]

Gene ID: 6189, updated on 9-Feb-2020

Summary

Official Symbol
RPS3Aprovided by HGNC
Official Full Name
ribosomal protein S3Aprovided by HGNC
Primary source
HGNC:HGNC:10421
See related
Ensembl:ENSG00000145425 MIM:180478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S3A; FTE1; MFTL
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in ovary (RPKM 854.6), bone marrow (RPKM 571.2) and 25 other tissues See more
Orthologs

Genomic context

See RPS3A in Genome Data Viewer
Location:
4q31.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (151099573..151104642)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (152020725..152025804)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene LPS responsive beige-like anchor protein Neighboring gene LRBA intron ENCODE-defined enhancer Neighboring gene uncharacterized LOC107986196 Neighboring gene adenylate kinase 4 pseudogene 6 Neighboring gene small nucleolar RNA, C/D box U73B Neighboring gene small nucleolar RNA, C/D box 73A Neighboring gene uncharacterized LOC105377485 Neighboring gene SH3 domain containing 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, ribosomal protein S3A (RPS3A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human ribosomal protein S3A (RPS3A) at amino acid residues 66-67 and 69-70 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC23240

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation IC
Inferred by Curator
more info
PubMed 
translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
PubMed 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm HDA PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit HDA PubMed 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
nucleolus HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
40S ribosomal protein S3a
Names
fte-1
small ribosomal subunit protein eS1
v-fos transformation effector protein 1
NP_000997.1
NP_001254628.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006.5NP_000997.1  40S ribosomal protein S3a isoform 1

    See identical proteins and their annotated locations for NP_000997.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC001708, CA441711
    Consensus CDS
    CCDS3775.1
    UniProtKB/Swiss-Prot
    P61247
    Related
    ENSP00000346050.3, ENST00000274065.9
    Conserved Domains (1) summary
    pfam01015
    Location:21221
    Ribosomal_S3Ae; Ribosomal S3Ae family
  2. NM_001267699.1NP_001254628.1  40S ribosomal protein S3a isoform 2

    See identical proteins and their annotated locations for NP_001254628.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal coding exon and differs at the 3' end compared to variant 1, which results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AI038646, AK296121, AK308947, CN315189, CX754149
    UniProtKB/TrEMBL
    B7Z3M5
    Conserved Domains (1) summary
    cl00821
    Location:2150
    Ribosomal_S3Ae; Ribosomal S3Ae family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    151099573..151104642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center