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RPS3 ribosomal protein S3 [ Homo sapiens (human) ]

Gene ID: 6188, updated on 13-May-2022

Summary

Official Symbol
RPS3provided by HGNC
Official Full Name
ribosomal protein S3provided by HGNC
Primary source
HGNC:HGNC:10420
See related
Ensembl:ENSG00000149273 MIM:600454; AllianceGenome:HGNC:10420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S3
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in ovary (RPKM 566.1), bone marrow (RPKM 278.4) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See RPS3 in Genome Data Viewer
Location:
11q13.4
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (75399518..75422302)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (75329106..75351811)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (75110562..75133346)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene trophoblast glycoprotein like Neighboring gene arrestin beta 1 Neighboring gene microRNA 326 Neighboring gene small nucleolar RNA, C/D box 15A Neighboring gene small nucleolar RNA, C/D box 15B Neighboring gene Sharpr-MPRA regulatory regions 6111 and 12908 Neighboring gene kelch like family member 35 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5 Neighboring gene uncharacterized LOC105369389

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S3 (RPS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S3 (RPS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S3 (RPS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag HIV-1 Gag interacts with RPS3 as demonstrated by proximity dependent biotinylation proteomics PubMed
gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S3 (RPS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26283, FLJ27450, MGC87870

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables DNA N-glycosylase activity TAS
Traceable Author Statement
more info
PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables Hsp70 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables endodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables iron-sulfur cluster binding NAS
Non-traceable Author Statement
more info
PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidized purine DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidized pyrimidine DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables small ribosomal subunit rRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
enables supercoiled DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-like protein conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to DNA damage stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to tumor necrosis factor IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytoplasmic translation IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of base-excision repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to TNF agonist IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in translation IC
Inferred by Curator
more info
PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of NF-kappaB complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IC
Inferred by Curator
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytosolic small ribosomal subunit HDA PubMed 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cytosolic small ribosomal subunit IC
Inferred by Curator
more info
PubMed 
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane HDA PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of polysome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in ribosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
40S ribosomal protein S3
Names
IMR-90 ribosomal protein S3
small ribosomal subunit protein uS3
NP_000996.2
NP_001243731.1
NP_001247435.1
NP_001247436.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005.5NP_000996.2  40S ribosomal protein S3 isoform 1

    See identical proteins and their annotated locations for NP_000996.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 both encode the same protein (isoform 1).
    Source sequence(s)
    AP000744, BC034149, CB241053
    Consensus CDS
    CCDS8236.1
    UniProtKB/Swiss-Prot
    P23396
    Related
    ENSP00000434643.1, ENST00000531188.6
    Conserved Domains (1) summary
    PTZ00084
    Location:4216
    PTZ00084; 40S ribosomal protein S3; Provisional
  2. NM_001256802.2NP_001243731.1  40S ribosomal protein S3 isoform 1

    See identical proteins and their annotated locations for NP_001243731.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein (isoform 1).
    Source sequence(s)
    AA976344, AW134501, BC034149
    Consensus CDS
    CCDS8236.1
    UniProtKB/Swiss-Prot
    P23396
    Related
    ENSP00000436971.1, ENST00000527446.5
    Conserved Domains (1) summary
    PTZ00084
    Location:4216
    PTZ00084; 40S ribosomal protein S3; Provisional
  3. NM_001260506.2NP_001247435.1  40S ribosomal protein S3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has two additional segments, one in the coding region and one in the 3' UTR, compared to variant 1. The resulting isoform (2) is longer and has an additional segment in the central region, compared to isoform 1.
    Source sequence(s)
    AP000744, BM831460, BM928330, BQ645330, CB241053, DW448503
    Consensus CDS
    CCDS58161.1
    UniProtKB/Swiss-Prot
    P23396
    Related
    ENSP00000278572.6, ENST00000278572.10
    Conserved Domains (1) summary
    PTZ00084
    Location:4232
    PTZ00084; 40S ribosomal protein S3; Provisional
  4. NM_001260507.2NP_001247436.1  40S ribosomal protein S3 isoform 3

    See identical proteins and their annotated locations for NP_001247436.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region, which results in a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AP000744, BC013231, BE797417, BM831460, CB241053
    UniProtKB/Swiss-Prot
    P23396
    Related
    ENSP00000416745.2, ENST00000422465.6
    Conserved Domains (1) summary
    PTZ00084
    Location:190
    PTZ00084; 40S ribosomal protein S3; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    75399518..75422302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    75329106..75351811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)