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Rps3 ribosomal protein S3 [ Mus musculus (house mouse) ]

Gene ID: 27050, updated on 1-Mar-2024

Summary

Official Symbol
Rps3provided by MGI
Official Full Name
ribosomal protein S3provided by MGI
Primary source
MGI:MGI:1350917
See related
Ensembl:ENSMUSG00000030744 AllianceGenome:MGI:1350917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rs_3; D7Ertd795e
Summary
Enables DNA-(apurinic or apyrimidinic site) endonuclease activity. Involved in positive regulation of NF-kappaB transcription factor activity and positive regulation of protein-containing complex assembly. Located in cytoplasm. Is active in synapse. Is expressed in metanephros and pancreas epithelium. Orthologous to human RPS3 (ribosomal protein S3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 369.2), CNS E11.5 (RPKM 356.1) and 28 other tissues See more
Orthologs
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Genomic context

See Rps3 in Genome Data Viewer
Location:
7 E1; 7 54.07 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99127103..99132916, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99477896..99483709, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1346 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_19652 Neighboring gene STARR-seq mESC enhancer starr_19653 Neighboring gene STARR-seq mESC enhancer starr_19654 Neighboring gene STARR-seq mESC enhancer starr_19655 Neighboring gene kelch-like 35 Neighboring gene small nucleolar RNA, C/D box 15B Neighboring gene small nucleolar RNA, C/D box 15A Neighboring gene predicted gene, 39056 Neighboring gene predicted gene, 40450 Neighboring gene predicted gene, 34172

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidized purine DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidized pyrimidine DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables small ribosomal subunit rRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
 
enables supercoiled DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like protein conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of base-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to TNF agonist ISO
Inferred from Sequence Orthology
more info
 
involved_in spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of NF-kappaB complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
PubMed 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
part_of small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
small ribosomal subunit protein uS3
Names
40S ribosomal protein S3
NP_036182.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012052.2NP_036182.1  small ribosomal subunit protein uS3

    See identical proteins and their annotated locations for NP_036182.1

    Status: VALIDATED

    Source sequence(s)
    AC115858, AK164077, CJ074413
    Consensus CDS
    CCDS40031.1
    UniProtKB/Swiss-Prot
    P17073, P47933, P62908
    UniProtKB/TrEMBL
    Q3UCL7, Q5YLW3, Q9CZP6, Q9D0A2
    Related
    ENSMUSP00000032998.7, ENSMUST00000032998.13
    Conserved Domains (1) summary
    PTZ00084
    Location:4216
    PTZ00084; 40S ribosomal protein S3; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    99127103..99132916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)