Format

Send to:

Choose Destination

RPL34 ribosomal protein L34 [ Homo sapiens (human) ]

Gene ID: 6164, updated on 9-Feb-2020

Summary

Official Symbol
RPL34provided by HGNC
Official Full Name
ribosomal protein L34provided by HGNC
Primary source
HGNC:HGNC:10340
See related
Ensembl:ENSG00000109475 MIM:616862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L34
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Overexpression of this gene has been observed in some cancer cells. Alternative splicing results in multiple transcript variants, all encoding the same isoform. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in ovary (RPKM 324.7), bone marrow (RPKM 227.1) and 25 other tissues See more
Orthologs

Genomic context

See RPL34 in Genome Data Viewer
Location:
4q25
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (108620558..108630484)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (109541722..109551640)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RPL34 divergent transcript Neighboring gene uncharacterized LOC101929621 Neighboring gene VISTA enhancer hs1050 Neighboring gene RNA, U6 small nuclear 431, pseudogene Neighboring gene oligosaccharyltransferase complex non-catalytic subunit Neighboring gene uncharacterized LOC105377359

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with RPL34 as demonstrated by proximity dependent biotinylation proteomics PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111005

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
60S ribosomal protein L34
Names
large ribosomal subunit protein eL34
leukemia-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000995.4NP_000986.2  60S ribosomal protein L34

    See identical proteins and their annotated locations for NP_000986.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1-6 all encode the same protein.
    Source sequence(s)
    BC106009, BM971961, CD249923
    Consensus CDS
    CCDS3680.1
    UniProtKB/Swiss-Prot
    P49207
    UniProtKB/TrEMBL
    A0A024RDH8
    Conserved Domains (1) summary
    pfam01199
    Location:196
    Ribosomal_L34e; Ribosomal protein L34e
  2. NM_001319232.1NP_001306161.1  60S ribosomal protein L34

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.
    Source sequence(s)
    AA128015, AA128058, CD175155, DA779124
    Consensus CDS
    CCDS3680.1
    UniProtKB/Swiss-Prot
    P49207
    UniProtKB/TrEMBL
    A0A024RDH8
    Related
    ENSP00000423316.1, ENST00000506397.5
    Conserved Domains (1) summary
    pfam01199
    Location:196
    Ribosomal_L34e; Ribosomal protein L34e
  3. NM_001319234.1NP_001306163.1  60S ribosomal protein L34

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.
    Source sequence(s)
    CB132938, DA779124
    Consensus CDS
    CCDS3680.1
    UniProtKB/Swiss-Prot
    P49207
    UniProtKB/TrEMBL
    A0A024RDH8
    Conserved Domains (1) summary
    pfam01199
    Location:196
    Ribosomal_L34e; Ribosomal protein L34e
  4. NM_001319235.1NP_001306164.1  60S ribosomal protein L34

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.
    Source sequence(s)
    BE394007, CD175155, DA779124
    Consensus CDS
    CCDS3680.1
    UniProtKB/Swiss-Prot
    P49207
    UniProtKB/TrEMBL
    A0A024RDH8
    Related
    ENSP00000378160.1, ENST00000394665.5
    Conserved Domains (1) summary
    pfam01199
    Location:196
    Ribosomal_L34e; Ribosomal protein L34e
  5. NM_001319236.1NP_001306165.1  60S ribosomal protein L34

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.
    Source sequence(s)
    BC106009, CD249923, DA779124
    Consensus CDS
    CCDS3680.1
    UniProtKB/Swiss-Prot
    P49207
    UniProtKB/TrEMBL
    A0A024RDH8
    Related
    ENSP00000378162.3, ENST00000394667.7
    Conserved Domains (1) summary
    pfam01199
    Location:196
    Ribosomal_L34e; Ribosomal protein L34e
  6. NM_033625.3NP_296374.1  60S ribosomal protein L34

    See identical proteins and their annotated locations for NP_296374.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1-6 all encode the same protein.
    Source sequence(s)
    BC001773, BM971961, CD175155
    Consensus CDS
    CCDS3680.1
    UniProtKB/Swiss-Prot
    P49207
    UniProtKB/TrEMBL
    A0A024RDH8
    Related
    ENSP00000378163.2, ENST00000394668.2
    Conserved Domains (1) summary
    pfam01199
    Location:196
    Ribosomal_L34e; Ribosomal protein L34e

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    108620558..108630484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center