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RPL28 ribosomal protein L28 [ Homo sapiens (human) ]

Gene ID: 6158, updated on 5-Jan-2020

Summary

Official Symbol
RPL28provided by HGNC
Official Full Name
ribosomal protein L28provided by HGNC
Primary source
HGNC:HGNC:10330
See related
Ensembl:ENSG00000108107 MIM:603638
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L28
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in spleen (RPKM 70.1), ovary (RPKM 68.3) and 25 other tissues See more
Orthologs

Genomic context

See RPL28 in Genome Data Viewer
Location:
19q13.42
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (55385932..55403342)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55897300..55914616)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 190 Neighboring gene transmembrane protein 238 Neighboring gene microRNA 6805 Neighboring gene ubiquitin conjugating enzyme E2 S Neighboring gene small nucleolar RNA, C/D box 157 Neighboring gene uncharacterized LOC105372462 Neighboring gene Sharpr-MPRA regulatory region 8373 Neighboring gene shisa family member 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with RPL28 as demonstrated by proximity dependent biotinylation proteomics PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43307

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
60S ribosomal protein L28
Names
large ribosomal subunit protein eL28
NP_000982.2
NP_001129606.1
NP_001129607.1
NP_001129608.1
NP_001129609.1
NP_001350626.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000991.5NP_000982.2  60S ribosomal protein L28 isoform 2

    See identical proteins and their annotated locations for NP_000982.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a stop-codon-containing segment in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a distinct and shorter C-terminus when compared to isoform 1.
    Source sequence(s)
    AC020922, AK311760, BC011582
    Consensus CDS
    CCDS12924.1
    UniProtKB/Swiss-Prot
    P46779
    Related
    ENSP00000342787.2, ENST00000344063.6
    Conserved Domains (1) summary
    pfam01778
    Location:5117
    Ribosomal_L28e; Ribosomal L28e protein family
  2. NM_001136134.1NP_001129606.1  60S ribosomal protein L28 isoform 1

    See identical proteins and their annotated locations for NP_001129606.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC020922, AK293736, BC011582
    Consensus CDS
    CCDS46190.1
    UniProtKB/Swiss-Prot
    P46779
    Related
    ENSP00000453029.1, ENST00000560583.5
    Conserved Domains (1) summary
    pfam01778
    Location:5109
    Ribosomal_L28e; Ribosomal L28e protein family
  3. NM_001136135.2NP_001129607.1  60S ribosomal protein L28 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a stop-codon-containing segment in the 3' coding region, compared to variant 1. The encoded protein (isoform 3) has a distinct and longer C-terminus when compared to isoform 1.
    Source sequence(s)
    AC020922, BC011582, BP227047
    Consensus CDS
    CCDS46189.1
    UniProtKB/Swiss-Prot
    P46779
    Related
    ENSP00000452909.1, ENST00000558815.5
    Conserved Domains (1) summary
    pfam01778
    Location:5112
    Ribosomal_L28e; Ribosomal L28e protein family
  4. NM_001136136.1NP_001129608.1  60S ribosomal protein L28 isoform 4

    See identical proteins and their annotated locations for NP_001129608.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The encoded protein (isoform 4) has a distinct and shorter C-terminus when compared to isoform 1.
    Source sequence(s)
    DA333143, DA820669
    Consensus CDS
    CCDS46192.1
    UniProtKB/Swiss-Prot
    P46779
    Related
    ENSP00000400596.2, ENST00000431533.6
    Conserved Domains (1) summary
    pfam01778
    Location:566
    Ribosomal_L28e; Ribosomal L28e protein family
  5. NM_001136137.1NP_001129609.1  60S ribosomal protein L28 isoform 5

    See identical proteins and their annotated locations for NP_001129609.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The encoded protein (isoform 5) has a distinct and shorter C-terminus when compared to isoform 1.
    Source sequence(s)
    BM702093, DA092122
    Consensus CDS
    CCDS46191.1
    UniProtKB/Swiss-Prot
    P46779
    Related
    ENSP00000391665.2, ENST00000428193.6
    Conserved Domains (1) summary
    pfam01778
    Location:568
    Ribosomal_L28e; Ribosomal L28e protein family
  6. NM_001363697.1NP_001350626.1  60S ribosomal protein L28 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AA579944, AK311760, BF686026, BG716117, DB540276
    Consensus CDS
    CCDS86809.1
    Related
    ENSP00000452763.1, ENST00000560055.5
    Conserved Domains (1) summary
    pfam01778
    Location:5110
    Ribosomal_L28e; Ribosomal L28e protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    55385932..55403342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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