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RPL27 ribosomal protein L27 [ Homo sapiens (human) ]

Gene ID: 6155, updated on 11-Jun-2021

Summary

Official Symbol
RPL27provided by HGNC
Official Full Name
ribosomal protein L27provided by HGNC
Primary source
HGNC:HGNC:10328
See related
Ensembl:ENSG00000131469 MIM:607526
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L27; DBA16
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L27e family of ribosomal proteins and a component of the 60S subunit. A splice site mutation in this gene has been identified in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]
Expression
Ubiquitous expression in bone marrow (RPKM 537.2), ovary (RPKM 510.1) and 25 other tissues See more
Orthologs
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Genomic context

See RPL27 in Genome Data Viewer
Location:
17q21.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (42998273..43002959)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41150290..41154976)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene PTGES3L-AARSD1 readthrough Neighboring gene prostaglandin E synthase 3 like Neighboring gene RUN domain containing 1 Neighboring gene interferon induced protein 35 Neighboring gene vesicle amine transport 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, ribosomal protein L27 (RPL27), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of ribosomal protein L27 (RPL27) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
enables structural constituent of ribosome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L27
Names
large ribosomal subunit protein eL27
NP_000979.1
NP_001336850.1
NP_001336851.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053099.1 RefSeqGene

    Range
    5147..9687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1156

mRNA and Protein(s)

  1. NM_000988.5NP_000979.1  60S ribosomal protein L27

    See identical proteins and their annotated locations for NP_000979.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the protein. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC055866
    Consensus CDS
    CCDS11449.1
    UniProtKB/Swiss-Prot
    P61353
    UniProtKB/TrEMBL
    A0A024R1V4
    Related
    ENSP00000253788.5, ENST00000253788.12
    Conserved Domains (1) summary
    cl00354
    Location:1136
    KOW; an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese)
  2. NM_001349921.2NP_001336850.1  60S ribosomal protein L27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC098560, BP203677
    Consensus CDS
    CCDS11449.1
    Related
    ENSP00000467587.1, ENST00000589037.5
    Conserved Domains (1) summary
    cl00354
    Location:1136
    KOW; an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese)
  3. NM_001349922.2NP_001336851.1  60S ribosomal protein L27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) retains an intron in its 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC055866, AW404176, BC098560, CN302602
    Consensus CDS
    CCDS11449.1
    Related
    ENSP00000464813.1, ENST00000589913.6
    Conserved Domains (1) summary
    cl00354
    Location:1136
    KOW; an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese)

RNA

  1. NR_146327.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC098560, BU955518, HY108539
    Related
    ENST00000588830.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    42998273..43002959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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