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RPL23A ribosomal protein L23a [ Homo sapiens (human) ]

Gene ID: 6147, updated on 9-Aug-2020

Summary

Official Symbol
RPL23Aprovided by HGNC
Official Full Name
ribosomal protein L23aprovided by HGNC
Primary source
HGNC:HGNC:10317
See related
Ensembl:ENSG00000198242 MIM:602326
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L23A; MDA20
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 799.6), lymph node (RPKM 457.6) and 25 other tissues See more
Orthologs

Genomic context

See RPL23A in Genome Data Viewer
Location:
17q11.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (28719985..28724359)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27047000..27051374)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene protein interacting with cyclin A1 Neighboring gene RAB34, member RAS oncogene family Neighboring gene small nucleolar RNA, C/D box 42B Neighboring gene small nucleolar RNA, C/D box 4A Neighboring gene small nucleolar RNA, C/D box 42A Neighboring gene small nucleolar RNA, C/D box 4B Neighboring gene TLC domain containing 1 Neighboring gene NIMA related kinase 8 Neighboring gene Sharpr-MPRA regulatory region 11843 Neighboring gene TNF receptor associated factor 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of ribosomal protein L23a (RPL23A) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27455

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
TORC2 complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
rRNA binding IEA
Inferred from Electronic Annotation
more info
 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
60S ribosomal protein L23a
Names
large ribosomal subunit protein uL23
melanoma differentiation-associated gene 20

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000984.6NP_000975.2  60S ribosomal protein L23a

    See identical proteins and their annotated locations for NP_000975.2

    Status: REVIEWED

    Source sequence(s)
    AC010761, BC058041, BE464375, U43701
    Consensus CDS
    CCDS11241.1
    UniProtKB/Swiss-Prot
    P62750
    Related
    ENSP00000389103.2, ENST00000422514.7
    Conserved Domains (1) summary
    PTZ00191
    Location:36156
    PTZ00191; 60S ribosomal protein L23a; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    28719985..28724359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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