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RPL23A ribosomal protein L23a [ Homo sapiens (human) ]

Gene ID: 6147, updated on 22-Sep-2022


Official Symbol
RPL23Aprovided by HGNC
Official Full Name
ribosomal protein L23aprovided by HGNC
Primary source
See related
Ensembl:ENSG00000198242 MIM:602326; AllianceGenome:HGNC:10317
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L23A; MDA20
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Ubiquitous expression in ovary (RPKM 799.6), lymph node (RPKM 457.6) and 25 other tissues See more
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Genomic context

See RPL23A in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28719985..28724359)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (29662794..29667166)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27047003..27051377)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene protein interacting with cyclin A1 Neighboring gene RAB34, member RAS oncogene family Neighboring gene small nucleolar RNA, C/D box 42B Neighboring gene small nucleolar RNA, C/D box 4A Neighboring gene small nucleolar RNA, C/D box 42A Neighboring gene small nucleolar RNA, C/D box 4B Neighboring gene TLC domain containing 1 Neighboring gene NIMA related kinase 8 Neighboring gene Sharpr-MPRA regulatory region 11843 Neighboring gene TNF receptor associated factor 4

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of ribosomal protein L23a (RPL23A) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • FLJ27455

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables TORC2 complex binding ISS
Inferred from Sequence or Structural Similarity
more info
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
involved_in translation NAS
Non-traceable Author Statement
more info

General protein information

Preferred Names
60S ribosomal protein L23a
large ribosomal subunit protein uL23
melanoma differentiation-associated gene 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000984.6NP_000975.2  60S ribosomal protein L23a

    See identical proteins and their annotated locations for NP_000975.2

    Status: REVIEWED

    Source sequence(s)
    AC010761, BC058041, BE464375, U43701
    Consensus CDS
    P62750, Q92774
    ENSP00000389103.2, ENST00000422514.7
    Conserved Domains (1) summary
    PTZ00191; 60S ribosomal protein L23a; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060941.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)