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RPL18A ribosomal protein L18a [ Homo sapiens (human) ]

Gene ID: 6142, updated on 5-Jul-2020


Official Symbol
RPL18Aprovided by HGNC
Official Full Name
ribosomal protein L18aprovided by HGNC
Primary source
See related
Ensembl:ENSG00000105640 MIM:604178
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]
Ubiquitous expression in ovary (RPKM 1039.7), lymph node (RPKM 680.9) and 25 other tissues See more

Genomic context

See RPL18A in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (17859910..17863319)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17970687..17974133)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene insulin like 3 Neighboring gene Janus kinase 3 Neighboring gene small nucleolar RNA, H/ACA box 68 Neighboring gene solute carrier family 5 member 5 Neighboring gene coiled-coil domain containing 124

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L18A (RPL18A) at amino acid residues 127-128 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
cytoplasmic translation IDA
Inferred from Direct Assay
more info
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
response to antineoplastic agent IEA
Inferred from Electronic Annotation
more info
translation NAS
Non-traceable Author Statement
more info
translational initiation TAS
Traceable Author Statement
more info
viral transcription TAS
Traceable Author Statement
more info
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
membrane HDA PubMed 
polysomal ribosome IDA
Inferred from Direct Assay
more info
postsynaptic density IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
60S ribosomal protein L18a
large ribosomal subunit protein eL20
ribosomal protein L18a-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000980.4NP_000971.1  60S ribosomal protein L18a

    See identical proteins and their annotated locations for NP_000971.1

    Status: REVIEWED

    Source sequence(s)
    BC007512, BI753938, HY050156
    Consensus CDS
    ENSP00000222247.4, ENST00000222247.10
    Conserved Domains (1) summary
    RPL20A; Ribosomal protein L20A (L18A) [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)
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