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EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 611397, updated on 17-Aug-2024

Summary

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Official Symbol
EIF2AK2provided by VGNC
Official Full Name
eukaryotic translation initiation factor 2 alpha kinase 2provided by VGNC
Primary source
VGNC:VGNC:40257
See related
Ensembl:ENSCAFG00845018782
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (30145828..30187548, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (29310721..29351697, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (29654942..29696294, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (29373804..29415016, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (29436846..29477968, complement)

Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene HEAT repeat containing 5B Neighboring gene G-patch domain containing 11 Neighboring gene uncharacterized LOC111090573 Neighboring gene sulfotransferase family 6B member 1 Neighboring gene CEBPZ opposite strand Neighboring gene CCAAT enhancer binding protein zeta Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7 Neighboring gene protein kinase D3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells. Groskreutz DJ, et al. J Immunol, 2006 Feb 1. PMID 16424203
  2. Comparative analysis of vertebrate EIF2AK2 (PKR) genes and assignment of the equine gene to ECA15q24-q25 and the bovine gene to BTA11q12-q15. Perelygin AA, et al. Genet Sel Evol, 2006 Sep-Oct. PMID 16954046, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Respiratory syncytial virus, via an effect on TLR3 and protein kinase R, sensitizes airway epithelial cells to subsequent double-stranded (ds)RNA exposure.
    Title: Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interferon-induced, double-stranded RNA-activated protein kinase
Names
P1/eIF-2A protein kinase
interferon-inducible RNA-dependent protein kinase
p68 kinase
NP_001041600.1
XP_038546438.1
XP_038546439.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048135.1 → NP_001041600.1  interferon-induced, double-stranded RNA-activated protein kinase

    See identical proteins and their annotated locations for NP_001041600.1

    Status: PROVISIONAL

    Source sequence(s)
    AY906960
    UniProtKB/TrEMBL
    A0A8C0LAY4, A0A8C0TR41, Q2KM13
    Conserved Domains (3) summary
    cd19903
    Location:9 → 75
    DSRM_EIF2AK2_rpt1; first double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
    cd19904
    Location:102 → 169
    DSRM_EIF2AK2_rpt2; second double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
    cl21453
    Location:258 → 518
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051821.1 Reference ROS_Cfam_1.0

    Range
    30145828..30187548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038690510.1 → XP_038546438.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8C0LAY4, A0A8C0TR41, Q2KM13
    Related
    ENSCAFP00845026003.1, ENSCAFT00845033215.1
    Conserved Domains (3) summary
    cd19903
    Location:9 → 75
    DSRM_EIF2AK2_rpt1; first double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
    cd19904
    Location:102 → 169
    DSRM_EIF2AK2_rpt2; second double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
    cl21453
    Location:258 → 518
    PKc_like; Protein Kinases, catalytic domain

  2. XM_038690511.1 → XP_038546439.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8C0LAY4, A0A8C0TR41, Q2KM13
    Conserved Domains (3) summary
    cd19903
    Location:9 → 75
    DSRM_EIF2AK2_rpt1; first double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
    cd19904
    Location:102 → 169
    DSRM_EIF2AK2_rpt2; second double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
    cl21453
    Location:258 → 518
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049277.1 Alternate UMICH_Zoey_3.1

    Range
    29373804..29415016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

    Range
    29436846..29477968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

    Range
    29654942..29696294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    29310721..29351697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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