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Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 19106, updated on 9-Mar-2023

Summary

Official Symbol
Eif2ak2provided by MGI
Official Full Name
eukaryotic translation initiation factor 2-alpha kinase 2provided by MGI
Primary source
MGI:MGI:1353449
See related
Ensembl:ENSMUSG00000024079 AllianceGenome:MGI:1353449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkr; Tik; Prkr; 2310047A08Rik; 4732414G15Rik
Summary
Enables double-stranded RNA binding activity and protein kinase activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of intracellular signal transduction; and regulation of hematopoietic stem cell differentiation. Acts upstream of or within cellular protein metabolic process; endoplasmic reticulum unfolded protein response; and negative regulation of apoptotic process. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 2.5), placenta adult (RPKM 2.4) and 27 other tissues See more
Orthologs
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Genomic context

See Eif2ak2 in Genome Data Viewer
Location:
17 E3; 17 49.56 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (79157933..79190001, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (78850504..78882572, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene HEAT repeat containing 5B Neighboring gene G patch domain containing 11 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene predicted gene, 26637 Neighboring gene sulfotransferase family, cytosolic, 6B, member 1 Neighboring gene CCAAT/enhancer binding protein (C/EBP), zeta, opposite strand Neighboring gene CCAAT/enhancer binding protein zeta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of NLRP3 inflammasome complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to vitamin E ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within translation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon-induced, double-stranded RNA-activated protein kinase
Names
IFN- type I-induced and dsRNA-activated kinase
IFN-induced and double-stranded RNA-activated kinase
P1/eIF-2A protein kinase
T-cell viral integration site
dsRNA-activated kinase
eIF-2 alpha
eIF-2A protein kinase 2
interferon-inducible RNA-dependent protein kinase
p68 kinase
protein kinase R
protein kinase RNA-activated
protein kinase, interferon-inducible double stranded RNA dependent
serine/threonine-protein kinase TIK
tyrosine-protein kinase EIF2AK2
NP_035293.1
XP_006523926.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011163.4NP_035293.1  interferon-induced, double-stranded RNA-activated protein kinase

    See identical proteins and their annotated locations for NP_035293.1

    Status: VALIDATED

    Source sequence(s)
    AK028602, BU756642
    Consensus CDS
    CCDS28980.1
    UniProtKB/Swiss-Prot
    Q03963, Q62026
    Related
    ENSMUSP00000024884.5, ENSMUST00000024884.5
    Conserved Domains (3) summary
    smart00220
    Location:242445
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00358
    Location:974
    DSRM; Double-stranded RNA binding motif
    cl21453
    Location:235500
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    79157933..79190001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523863.5XP_006523926.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X1

    Conserved Domains (3) summary
    cd19903
    Location:2188
    DSRM_EIF2AK2_rpt1; first double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
    cd19904
    Location:108175
    DSRM_EIF2AK2_rpt2; second double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
    cl21453
    Location:249514
    PKc_like; Protein Kinases, catalytic domain