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GAS5 growth arrest specific 5 [ Homo sapiens (human) ]

Gene ID: 60674, updated on 17-May-2020

Summary

Official Symbol
GAS5provided by HGNC
Official Full Name
growth arrest specific 5provided by HGNC
Primary source
HGNC:HGNC:16355
See related
Ensembl:ENSG00000234741 MIM:608280
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNHG2; NCRNA00030
Summary
This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]
Expression
Ubiquitous expression in ovary (RPKM 307.5), thyroid (RPKM 113.4) and 24 other tissues See more
Orthologs

Genomic context

See GAS5 in Genome Data Viewer
Location:
1q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (173863899..173868882, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173833039..173837125, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene centromere protein L Neighboring gene aspartyl-tRNA synthetase 2, mitochondrial Neighboring gene GAS5 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 81 Neighboring gene small nucleolar RNA, C/D box 47 Neighboring gene small nucleolar RNA, H/ACA box 103 Neighboring gene small nucleolar RNA, C/D box 80 Neighboring gene small nucleolar RNA, C/D box 79 Neighboring gene small nucleolar RNA, C/D box 78 Neighboring gene small nucleolar RNA, C/D box 44 Neighboring gene small nucleolar RNA, C/D box 77 Neighboring gene small nucleolar RNA, C/D box 76 Neighboring gene small nucleolar RNA, C/D box 75 Neighboring gene small nucleolar RNA, C/D box 74 Neighboring gene zinc finger and BTB domain containing 37 Neighboring gene serpin family C member 1 Neighboring gene RNA, 5S ribosomal pseudogene 67

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CENPL

Homology

Other Names

  • growth arrest specific 5 (non-protein coding)
  • growth arrest specific transcript 5
  • small nucleolar RNA host gene (non-protein coding) 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_002578.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL110141, CA441479, DA317412
    Related
    ENST00000450589.5
  2. NR_152521.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000430245.5
  3. NR_152522.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
  4. NR_152523.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000448718.5
  5. NR_152524.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
  6. NR_152525.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BM744461, CA441479, DA317412
  7. NR_152526.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BM754005, CA441479, DA317412
  8. NR_152527.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    CA441479, CB151926, DA317412
  9. NR_152528.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    CA441479, CD174226, DA317412
  10. NR_152529.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    CA441479, CD175951, DA317412
    Related
    ENST00000449289.5
  11. NR_152530.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    CA441479, CD247817, DA317412
  12. NR_152531.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AV758168, CA441479, DA317412
  13. NR_152532.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BQ949316, CA441479, DA317412, HY063734
  14. NR_152533.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
  15. NR_152534.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BM853444, CA441479, DA317412

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    173863899..173868882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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