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GAS5 growth arrest specific 5 (non-protein coding) [ Homo sapiens (human) ]

Gene ID: 60674, updated on 24-Sep-2017
Official Symbol
GAS5provided by HGNC
Official Full Name
growth arrest specific 5 (non-protein coding)provided by HGNC
Primary source
HGNC:HGNC:16355
See related
Ensembl:ENSG00000234741 MIM:608280
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNHG2; NCRNA00030
Summary
This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]
Orthologs
Location:
1q25.1
Exon count:
12
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (173863901..173867987, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173833039..173837125, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene centromere protein L Neighboring gene aspartyl-tRNA synthetase 2, mitochondrial Neighboring gene GAS5 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 81 Neighboring gene small nucleolar RNA, C/D box 47 Neighboring gene small nucleolar RNA, H/ACA box 103 Neighboring gene small nucleolar RNA, C/D box 80 Neighboring gene small nucleolar RNA, C/D box 79 Neighboring gene small nucleolar RNA, C/D box 78 Neighboring gene small nucleolar RNA, C/D box 44 Neighboring gene small nucleolar RNA, C/D box 77 Neighboring gene small nucleolar RNA, C/D box 76 Neighboring gene small nucleolar RNA, C/D box 75 Neighboring gene small nucleolar RNA, C/D box 74 Neighboring gene zinc finger and BTB domain containing 37 Neighboring gene serpin family C member 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Potential readthrough

Included gene: CENPL

Homology

Other Names

  • growth arrest specific transcript 5
  • small nucleolar RNA host gene (non-protein coding) 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_002578.2 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL110141
    Related
    ENST00000450589.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

    Range
    173863901..173867987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    175255480..175259566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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