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CENPL centromere protein L [ Homo sapiens (human) ]

Gene ID: 91687, updated on 13-Mar-2020

Summary

Official Symbol
CENPLprovided by HGNC
Official Full Name
centromere protein Lprovided by HGNC
Primary source
HGNC:HGNC:17879
See related
Ensembl:ENSG00000120334 MIM:611503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENP-L; C1orf155; dJ383J4.3
Summary
CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 4.2), bone marrow (RPKM 2.4) and 22 other tissues See more
Orthologs

Genomic context

See CENPL in Genome Data Viewer
Location:
1q25.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (173799550..173824639, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173768688..173794325, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kelch like family member 20 Neighboring gene ribosomal protein S27 pseudogene 7 Neighboring gene RN7SK pseudogene 160 Neighboring gene aspartyl-tRNA synthetase 2, mitochondrial Neighboring gene GAS5 antisense RNA 1 Neighboring gene growth arrest specific 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31044, FLJ31786

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
centromere protein L
Names
interphase centromere complex protein 33

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127181.2NP_001120653.1  centromere protein L isoform 1

    See identical proteins and their annotated locations for NP_001120653.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC033154, DN995099
    Consensus CDS
    CCDS44277.1
    UniProtKB/Swiss-Prot
    Q8N0S6
    Related
    ENSP00000348527.2, ENST00000356198.6
    Conserved Domains (1) summary
    pfam13092
    Location:223369
    CENP-L; Kinetochore complex Sim4 subunit Fta1
  2. NM_001171182.1NP_001164653.1  centromere protein L isoform 2

    See identical proteins and their annotated locations for NP_001164653.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR and lacks an alternate in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BC019022, BC033154
    Consensus CDS
    CCDS30938.1
    UniProtKB/Swiss-Prot
    Q8N0S6
    UniProtKB/TrEMBL
    A0A024R932
    Related
    ENSP00000323543.7, ENST00000345664.10
    Conserved Domains (1) summary
    pfam13092
    Location:177323
    CENP-L; Kinetochore complex Sim4 subunit Fta1
  3. NM_033319.3NP_201576.1  centromere protein L isoform 2

    See identical proteins and their annotated locations for NP_201576.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame coding exon resulting in a shorter isoform (2).
    Source sequence(s)
    BC033154, BC066658, DN995099
    Consensus CDS
    CCDS30938.1
    UniProtKB/Swiss-Prot
    Q8N0S6
    UniProtKB/TrEMBL
    A0A024R932
    Related
    ENSP00000356683.3, ENST00000367710.7
    Conserved Domains (1) summary
    pfam13092
    Location:177323
    CENP-L; Kinetochore complex Sim4 subunit Fta1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    173799550..173824639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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