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Sap30 sin3 associated polypeptide [ Mus musculus (house mouse) ]

Gene ID: 60406, updated on 8-Feb-2024

Summary

Official Symbol
Sap30provided by MGI
Official Full Name
sin3 associated polypeptideprovided by MGI
Primary source
MGI:MGI:1929129
See related
Ensembl:ENSMUSG00000031609 AllianceGenome:MGI:1929129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
30kDa
Summary
Predicted to enable transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including branchial arch; early embryo; embryo mesenchyme; forelimb bud; and sensory organ. Orthologous to human SAP30 (Sin3A associated protein 30). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 34.9), CNS E14 (RPKM 18.2) and 26 other tissues See more
Orthologs
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Genomic context

See Sap30 in Genome Data Viewer
Location:
8 B2; 8 29.85 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (57935740..57940874, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (57482702..57487860, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene mannosidase 2, alpha 2 pseudogene Neighboring gene scrapie responsive gene 1 Neighboring gene STARR-seq mESC enhancer starr_21527 Neighboring gene RIKEN cDNA 2500002B13 gene Neighboring gene STARR-positive B cell enhancer ABC_E1755 Neighboring gene STARR-seq mESC enhancer starr_21528 Neighboring gene STARR-seq mESC enhancer starr_21531 Neighboring gene high mobility group box 2 Neighboring gene predicted gene 6012

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Sin3-type complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
histone deacetylase complex subunit SAP30
Names
30 kDa Sin3-associated polypeptide
Sin3-associated protein
sin3 associated polypeptide, 30kD
sin3 corepressor complex subunit SAP30
sin3-associated polypeptide p30
sin3-associated polypeptide, 30 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021788.3NP_068560.1  histone deacetylase complex subunit SAP30

    See identical proteins and their annotated locations for NP_068560.1

    Status: VALIDATED

    Source sequence(s)
    AC130841
    Consensus CDS
    CCDS22316.1
    UniProtKB/Swiss-Prot
    A2RSE9, O88574, Q99JB9
    Related
    ENSMUSP00000034022.4, ENSMUST00000034022.4
    Conserved Domains (2) summary
    pfam13866
    Location:65133
    zf-SAP30; SAP30 zinc-finger
    pfam13867
    Location:153205
    SAP30_Sin3_bdg; Sin3 binding region of histone deacetylase complex subunit SAP30

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    57935740..57940874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)