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SAP30 Sin3A associated protein 30 [ Homo sapiens (human) ]

Gene ID: 8819, updated on 11-Sep-2019

Summary

Official Symbol
SAP30provided by HGNC
Official Full Name
Sin3A associated protein 30provided by HGNC
Primary source
HGNC:HGNC:10532
See related
Ensembl:ENSG00000164105 MIM:603378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 10.9), stomach (RPKM 8.8) and 25 other tissues See more
Orthologs

Genomic context

See SAP30 in Genome Data Viewer
Location:
4q34.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (173370954..173377532)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (174292093..174298683)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377541 Neighboring gene SAP30 divergent transcript Neighboring gene uncharacterized LOC101928383 Neighboring gene uncharacterized LOC112268474 Neighboring gene stimulator of chondrogenesis 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
histone deacetylase complex subunit SAP30
Names
30 kDa Sin3-associated polypeptide
Sin3 corepressor complex subunit SAP30
Sin3-associated polypeptide, 30kDa
Sin3A-associated protein, 30kDa
sin3-associated polypeptide p30
sin3-associated polypeptide, 30 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003864.4NP_003855.1  histone deacetylase complex subunit SAP30

    See identical proteins and their annotated locations for NP_003855.1

    Status: REVIEWED

    Source sequence(s)
    AF055993, AW236579, BC016757
    Consensus CDS
    CCDS3817.1
    UniProtKB/Swiss-Prot
    O75446
    Related
    ENSP00000296504.3, ENST00000296504.4
    Conserved Domains (2) summary
    pfam13866
    Location:65133
    zf-SAP30; SAP30 zinc-finger
    pfam13867
    Location:153205
    SAP30_Sin3_bdg; Sin3 binding region of histone deacetylase complex subunit SAP30

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    173370954..173377532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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