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BCL3 B cell CLL/lymphoma 3 [ Homo sapiens (human) ]

Gene ID: 602, updated on 8-Jul-2018
Official Symbol
BCL3provided by HGNC
Official Full Name
B cell CLL/lymphoma 3provided by HGNC
Primary source
HGNC:HGNC:998
See related
Ensembl:ENSG00000069399 MIM:109560; Vega:OTTHUMG00000151517
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCL4; D19S37
Summary
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 8.4), small intestine (RPKM 7.7) and 24 other tissues See more
Orthologs
See BCL3 in Genome Data Viewer
Location:
19q13.32
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (44742620..44760044)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45246070..45263301)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985305 Neighboring gene uncharacterized LOC107985306 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 16 Neighboring gene microRNA 8085 Neighboring gene Cbl proto-oncogene C Neighboring gene basal cell adhesion molecule (Lutheran blood group)

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
NHGRI GWA Catalog
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
NHGRI GWA Catalog
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of B-cell CLL/lymphoma 3 (BCL3) in human B cells PubMed
Tat tat HIV-1 Tat upregulates the expression of B-cell CLL/lymphoma 3 (BCL3) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging TAS
Traceable Author Statement
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
T-helper 1 type immune response IEA
Inferred from Electronic Annotation
more info
 
T-helper 2 cell differentiation IEA
Inferred from Electronic Annotation
more info
 
antimicrobial humoral response IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
defense response to protozoan IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
follicular dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
germinal center formation IEA
Inferred from Electronic Annotation
more info
 
humoral immune response mediated by circulating immunoglobulin IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of protein location in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
marginal zone B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of JAK-STAT cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-8 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-10 biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein import into nucleus, translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA binding IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of NIK/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
response to UV-C IDA
Inferred from Direct Assay
more info
PubMed 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
spleen development IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Bcl3-Bcl10 complex IDA
Inferred from Direct Assay
more info
PubMed 
Bcl3/NF-kappaB2 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
midbody IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
B-cell lymphoma 3 protein
Names
B-cell leukemia/lymphoma 3
B-cell lymphoma 3-encoded protein
BCL-3
chronic lymphatic leukemia protein
proto-oncogene BCL3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052809.1 RefSeqGene

    Range
    11101..22424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005178.4NP_005169.2  B-cell lymphoma 3 protein

    See identical proteins and their annotated locations for NP_005169.2

    Status: REVIEWED

    Source sequence(s)
    BC064993, BU501187
    Consensus CDS
    CCDS12642.2
    UniProtKB/Swiss-Prot
    P20749
    Related
    ENSP00000164227.5, OTTHUMP00000200151, ENST00000164227.9, OTTHUMT00000322976
    Conserved Domains (4) summary
    cd00204
    Location:237359
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:210305
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:157212
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:241272
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    44742620..44760044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527198.3XP_011525500.2  B-cell lymphoma 3 protein isoform X2

  2. XM_011527197.2XP_011525499.2  B-cell lymphoma 3 protein isoform X1

  3. XM_017027110.1XP_016882599.1  B-cell lymphoma 3 protein isoform X5

    UniProtKB/TrEMBL
    B7Z3N9
    Conserved Domains (4) summary
    cd00204
    Location:160289
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:170265
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:117172
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:201232
    ANK; ANK repeat [structural motif]
  4. XM_017027109.1XP_016882598.1  B-cell lymphoma 3 protein isoform X3

  5. XM_011527200.2XP_011525502.1  B-cell lymphoma 3 protein isoform X4

    Related
    ENSP00000393731.1, OTTHUMP00000200152, ENST00000444487.1, OTTHUMT00000322980
    Conserved Domains (4) summary
    cd00204
    Location:104233
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:114209
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:61116
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:145176
    ANK; ANK repeat [structural motif]
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