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Bcl3 B cell leukemia/lymphoma 3 [ Mus musculus (house mouse) ]

Gene ID: 12051, updated on 8-Dec-2022

Summary

Official Symbol
Bcl3provided by MGI
Official Full Name
B cell leukemia/lymphoma 3provided by MGI
Primary source
MGI:MGI:88140
See related
Ensembl:ENSMUSG00000053175 AllianceGenome:MGI:88140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bcl-3
Summary
Enables transcription coactivator activity. Acts upstream of or within several processes, including defense response to other organism; hematopoietic or lymphoid organ development; and regulation of gene expression. Predicted to be located in several cellular components, including cytosol; midbody; and nucleoplasm. Predicted to be part of Bcl3-Bcl10 complex and Bcl3/NF-kappaB2 complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; immune system; and liver and biliary system. Orthologous to human BCL3 (BCL3 transcription coactivator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 114.5), small intestine adult (RPKM 82.2) and 11 other tissues See more
Orthologs
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Genomic context

See Bcl3 in Genome Data Viewer
Location:
7 A3; 7 9.95 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19542387..19556691, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19808462..19822824, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34744 Neighboring gene basal cell adhesion molecule Neighboring gene Casitas B-lineage lymphoma c Neighboring gene predicted gene 16174 Neighboring gene predicted gene, 34891 Neighboring gene CEA cell adhesion molecule 16 Neighboring gene predicted gene, 19345

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Chemically induced (ENU) (3) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of T cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T-helper 1 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T-helper 2 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within antimicrobial humoral response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within follicular dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within germinal center formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within marginal zone B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of T cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV-C ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Bcl3-Bcl10 complex ISO
Inferred from Sequence Orthology
more info
 
part_of Bcl3/NF-kappaB2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Bcl3/NF-kappaB2 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
B-cell lymphoma 3 protein homolog
Names
B-cell CLL/lymphoma 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033601.3NP_291079.2  B-cell lymphoma 3 protein homolog

    See identical proteins and their annotated locations for NP_291079.2

    Status: VALIDATED

    Source sequence(s)
    AF067774, AI528691, BY749796
    Consensus CDS
    CCDS20914.2
    UniProtKB/Swiss-Prot
    Q9Z2F6
    Related
    ENSMUSP00000113851.2, ENSMUST00000120537.8
    Conserved Domains (3) summary
    COG0666
    Location:115222
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:236267
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:171267
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19542387..19556691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539487.5XP_006539550.1  B-cell lymphoma 3 protein homolog isoform X1

    Conserved Domains (3) summary
    COG0666
    Location:115222
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:236267
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:171267
    Ank_2; Ankyrin repeats (3 copies)