Format

Send to:

Choose Destination

RGS16 regulator of G protein signaling 16 [ Homo sapiens (human) ]

Gene ID: 6004, updated on 13-Mar-2020

Summary

Official Symbol
RGS16provided by HGNC
Official Full Name
regulator of G protein signaling 16provided by HGNC
Primary source
HGNC:HGNC:9997
See related
Ensembl:ENSG00000143333 MIM:602514
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGS-R; A28-RGS14; A28-RGS14P
Summary
The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]
Expression
Biased expression in thyroid (RPKM 20.2), lung (RPKM 3.6) and 11 other tissues See more
Orthologs

Genomic context

See RGS16 in Genome Data Viewer
Location:
1q25.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (182598623..182604389, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (182567758..182573548, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene regulator of G protein signaling like 1 Neighboring gene ribonuclease L Neighboring gene long intergenic non-protein coding RNA 1686 Neighboring gene regulator of G protein signaling 8 Neighboring gene long intergenic non-protein coding RNA 1688

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
 
calmodulin binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
visual perception TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 16
Names
hRGS-r
regulator of G-protein signalling 16
retinal-specific RGS
retinally abundant regulator of G-protein signaling

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002928.4NP_002919.3  regulator of G-protein signaling 16

    See identical proteins and their annotated locations for NP_002919.3

    Status: REVIEWED

    Source sequence(s)
    AL353778, BC006243, DA060276, DC349953
    Consensus CDS
    CCDS1348.1
    UniProtKB/Swiss-Prot
    O15492
    Related
    ENSP00000356529.5, ENST00000367558.6
    Conserved Domains (1) summary
    cd08710
    Location:66179
    RGS_RGS16; Regulator of G protein signaling (RGS) domain found in the RGS16 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    182598623..182604389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448796.1XP_024304564.1  regulator of G-protein signaling 16 isoform X1

    Conserved Domains (1) summary
    cd08710
    Location:65178
    RGS_RGS16; Regulator of G protein signaling (RGS) domain found in the RGS16 protein
Support Center