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RGS1 regulator of G protein signaling 1 [ Homo sapiens (human) ]

Gene ID: 5996, updated on 6-Sep-2021


Official Symbol
RGS1provided by HGNC
Official Full Name
regulator of G protein signaling 1provided by HGNC
Primary source
See related
Ensembl:ENSG00000090104 MIM:600323
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
1R20; BL34; IER1; IR20; HEL-S-87
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Broad expression in appendix (RPKM 110.9), lymph node (RPKM 72.3) and 17 other tissues See more
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Genomic context

See RGS1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (192575773..192580024)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192544903..192549154)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily E member 1 pseudogene Neighboring gene regulator of G protein signaling 21 Neighboring gene uncharacterized LOC105371664 Neighboring gene uncharacterized LOC107985241 Neighboring gene regulator of G protein signaling 13

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Associated conditions

Description Tests
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Multiple common variants for celiac disease influencing immune gene expression.
GeneReviews: Not available
Newly identified genetic risk variants for celiac disease related to the immune response.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of regulator of G-protein signaling 1 (RGS1) in human B cells PubMed
Tat tat HIV-1 Tat upregulates the expression of regulator of G-protein signaling 1 (RGS1) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
enables GTPase activity TAS
Traceable Author Statement
more info
enables calmodulin binding TAS
Traceable Author Statement
more info
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
located_in extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
located_in plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
regulator of G-protein signaling 1
B-cell activation protein BL34
early response protein 1R20
epididymis secretory protein Li 87
immediate-early response 1, B-cell specific
regulator of G-protein signalling 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002922.4NP_002913.3  regulator of G-protein signaling 1

    See identical proteins and their annotated locations for NP_002913.3

    Status: REVIEWED

    Source sequence(s)
    AL136987, BC015510, BG536972
    Consensus CDS
    ENSP00000356429.3, ENST00000367459.8
    Conserved Domains (1) summary
    RGS_RGS1; Regulator of G protein signaling (RGS) domain found in the RGS1 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)
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