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REN renin [ Homo sapiens (human) ]

Gene ID: 5972, updated on 13-Oct-2018

Summary

Official Symbol
RENprovided by HGNC
Official Full Name
reninprovided by HGNC
Primary source
HGNC:HGNC:9958
See related
Ensembl:ENSG00000143839 MIM:179820; Vega:OTTHUMG00000036059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNFJ2
Summary
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
Expression
Biased expression in kidney (RPKM 16.5), placenta (RPKM 13.8) and 2 other tissues See more
Orthologs

Genomic context

See REN in Genome Data Viewer
Location:
1q32.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (204154816..204166337, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (204123944..204135465, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SRY-box 13 Neighboring gene HNF4 motif-containing MPRA enhancer 209 Neighboring gene ethanolamine kinase 2 Neighboring gene estrogen receptor responsive lncRNA 1 Neighboring gene REN promoter and enhancer region Neighboring gene KiSS-1 metastasis suppressor Neighboring gene tripartite motif containing 60 pseudogene Neighboring gene golgi transport 1A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Renin cleaves HIV-1 Gag to enhance HIV-1 replication in human T cells PubMed
gag Renin modulates HIV-1 replication by enhancing HIV-1 Gag. CA/p24, and genomic RNA expressions in human T cells PubMed
capsid gag Renin modulates HIV-1 replication by enhancing HIV-1 Gag. CA/p24, and genomic RNA expressions in human T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • ACE Inhibitor Pathway, organism-specific biosystem (from WikiPathways)
    ACE Inhibitor Pathway, organism-specific biosystemThe core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by an...
  • Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystem (from REACTOME)
    Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystemAngiotensinogen, a prohormone, is synthesized and secreted mainly by the liver but also from other tissues (reviewed in Fyhrquist and Saijonmaa 2008, Cat and Touyz 2011). Renin, an aspartyl protease ...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
  • Renin secretion, organism-specific biosystem (from KEGG)
    Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin secretion, conserved biosystem (from KEGG)
    Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10761

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aspartic-type endopeptidase activity EXP
Inferred from Experiment
more info
PubMed 
aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aspartic-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 
angiotensin maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiotensin maturation IDA
Inferred from Direct Assay
more info
PubMed 
angiotensin maturation TAS
Traceable Author Statement
more info
 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
drinking behavior IEA
Inferred from Electronic Annotation
more info
 
hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
mesonephros development IEA
Inferred from Electronic Annotation
more info
 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
renin-angiotensin regulation of aldosterone production IEA
Inferred from Electronic Annotation
more info
 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to cGMP IEA
Inferred from Electronic Annotation
more info
 
response to immobilization stress IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
renin
Names
angiotensin-forming enzyme
angiotensinogenase
renin precursor, renal
NP_000528.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012122.1 RefSeqGene

    Range
    5001..16522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000537.3NP_000528.1  renin preproprotein

    See identical proteins and their annotated locations for NP_000528.1

    Status: REVIEWED

    Source sequence(s)
    BC033474, BP321283
    Consensus CDS
    CCDS30981.1
    UniProtKB/Swiss-Prot
    P00797
    Related
    ENSP00000272190.8, OTTHUMP00000034311, ENST00000272190.8, OTTHUMT00000087891
    Conserved Domains (2) summary
    cd05487
    Location:78405
    renin_like; Renin stimulates production of angiotensin and thus affects blood pressure
    pfam07966
    Location:3351
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    204154816..204166337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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