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Ren1 renin 1 structural [ Mus musculus (house mouse) ]

Gene ID: 19701, updated on 13-Feb-2024

Summary

Official Symbol
Ren1provided by MGI
Official Full Name
renin 1 structuralprovided by MGI
Primary source
MGI:MGI:97898
See related
Ensembl:ENSMUSG00000070645 AllianceGenome:MGI:97898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ren; Rnr; Rn-1; Ren-1; Ren-A; Ren1c; Ren1d
Summary
Enables endopeptidase activity. Acts upstream of or within with a positive effect on regulation of blood pressure. Acts upstream of or within several processes, including drinking behavior; male gonad development; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and trunk. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 87.3) and ovary adult (RPKM 3.3) See more
Orthologs
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Genomic context

See Ren1 in Genome Data Viewer
Location:
1 E4; 1 57.91 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133278412..133288058)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133350674..133360320)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene golgi transport 1A Neighboring gene predicted gene, 53474 Neighboring gene KiSS-1 metastasis-suppressor Neighboring gene Ren1 promoter and enhancer region Neighboring gene STARR-positive B cell enhancer ABC_E11089 Neighboring gene ethanolamine kinase 2 Neighboring gene SRY (sex determining region Y)-box 13 Neighboring gene STARR-seq mESC enhancer starr_02283

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aspartic-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in angiotensin maturation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within angiotensin maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiotensin maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within drinking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within establishment of blood-nerve barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hormone-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mesonephros development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_positive_effect regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of blood volume by renin-angiotensin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within renin-angiotensin regulation of aldosterone production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cGMP ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
renin-1
Names
angiotensinogenase
aspartyl-protease
kidney renin
renin b
NP_112469.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031192.3NP_112469.1  renin-1 precursor

    See identical proteins and their annotated locations for NP_112469.1

    Status: VALIDATED

    Source sequence(s)
    AC068906, AK085309
    Consensus CDS
    CCDS15295.1
    UniProtKB/Swiss-Prot
    P00796, P06281, P70229, P97911, P97955, Q543E5, Q62153, Q62154, Q62155
    Related
    ENSMUSP00000092135.3, ENSMUST00000094556.3
    Conserved Domains (3) summary
    cd05487
    Location:76401
    renin_like; Renin stimulates production of angiotensin and thus affects blood pressure
    pfam00026
    Location:83401
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:2954
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    133278412..133288058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)