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Ren1 renin 1 structural [ Mus musculus (house mouse) ]

Gene ID: 19701, updated on 23-May-2018
Official Symbol
Ren1provided by MGI
Official Full Name
renin 1 structuralprovided by MGI
Primary source
MGI:MGI:97898
See related
Ensembl:ENSMUSG00000070645 Vega:OTTMUSG00000021617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ren; Rnr; Rn-1; Ren-1; Ren-A; Ren1c; Ren1d; D19352
Expression
Biased expression in kidney adult (RPKM 87.3) and ovary adult (RPKM 3.3) See more
Orthologs
See Ren1 in Genome Data Viewer
Location:
1 E4; 1 57.91 cM
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (133350674..133360320)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (135247251..135256894)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family A member 6 Neighboring gene predicted gene, 19461 Neighboring gene golgi transport 1A Neighboring gene KiSS-1 metastasis-suppressor Neighboring gene ethanolamine kinase 2 Neighboring gene SRY (sex determining region Y)-box 13

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • ACE Inhibitor Pathway, organism-specific biosystem (from WikiPathways)
    ACE Inhibitor Pathway, organism-specific biosystemThe renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representatio...
  • Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystem (from REACTOME)
    Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Renin secretion, organism-specific biosystem (from KEGG)
    Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin secretion, conserved biosystem (from KEGG)
    Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aspartic-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
peptidase activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
angiotensin maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiotensin maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiotensin maturation ISO
Inferred from Sequence Orthology
more info
 
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
drinking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT establishment of blood-nerve barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
hormone-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
kidney development ISO
Inferred from Sequence Orthology
more info
 
male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
mesonephros development IEP
Inferred from Expression Pattern
more info
PubMed 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of blood volume by renin-angiotensin IMP
Inferred from Mutant Phenotype
more info
PubMed 
renin-angiotensin regulation of aldosterone production IDA
Inferred from Direct Assay
more info
PubMed 
response to cAMP ISO
Inferred from Sequence Orthology
more info
 
response to cGMP ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
renin-1
Names
angiotensinogenase
aspartyl-protease
kidney renin
renin b
NP_112469.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031192.3NP_112469.1  renin-1 precursor

    See identical proteins and their annotated locations for NP_112469.1

    Status: VALIDATED

    Source sequence(s)
    AC068906, AK085309
    Consensus CDS
    CCDS15295.1
    UniProtKB/Swiss-Prot
    P06281
    Related
    ENSMUSP00000092135.2, OTTMUSP00000024128, ENSMUST00000094556.2, OTTMUST00000051330
    Conserved Domains (3) summary
    cd05487
    Location:76401
    renin_like; Renin stimulates production of angiotensin and thus affects blood pressure
    pfam00026
    Location:83401
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:2954
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    133350674..133360320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p4 129S6/SvEvTac

Genomic

  1. NT_039192.2 Reference GRCm38.p4 129S6/SvEvTac

    Range
    129184..138826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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