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RBP4 retinol binding protein 4 [ Homo sapiens (human) ]

Gene ID: 5950, updated on 21-Jun-2020

Summary

Official Symbol
RBP4provided by HGNC
Official Full Name
retinol binding protein 4provided by HGNC
Primary source
HGNC:HGNC:9922
See related
Ensembl:ENSG00000138207 MIM:180250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RDCCAS; MCOPCB10
Summary
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 2545.8) and fat (RPKM 387.7) See more
Orthologs

Genomic context

See RBP4 in Genome Data Viewer
Location:
10q23.33
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (93591694..93601744, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (95351593..95361101, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378436 Neighboring gene free fatty acid receptor 4 Neighboring gene phosphodiesterase 6C Neighboring gene FRA10A associated CGG repeat 1 Neighboring gene fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
retinal binding IEA
Inferred from Electronic Annotation
more info
 
retinol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retinol binding IDA
Inferred from Direct Assay
more info
PubMed 
retinol transmembrane transporter activity IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
cardiac muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic organ morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic retina morphogenesis in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic skeletal system development ISS
Inferred from Sequence or Structural Similarity
more info
 
eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
eye development ISS
Inferred from Sequence or Structural Similarity
more info
 
female genitalia morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
heart trabecula formation ISS
Inferred from Sequence or Structural Similarity
more info
 
lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
maintenance of gastrointestinal epithelium IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of immunoglobulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
retinol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
retinol transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retinol transport IC
Inferred by Curator
more info
PubMed 
urinary bladder development ISS
Inferred from Sequence or Structural Similarity
more info
 
uterus development ISS
Inferred from Sequence or Structural Similarity
more info
 
vagina development ISS
Inferred from Sequence or Structural Similarity
more info
 
visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
retinol-binding protein 4
Names
PRBP
RBP
plasma retinol-binding protein
retinol binding protein 4, plasma
retinol-binding protein 4, interstitial

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009104.1 RefSeqGene

    Range
    5002..14543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001323517.1NP_001310446.1  retinol-binding protein 4 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) and variant 1 both encode isoform a.
    Source sequence(s)
    AL356214
    Consensus CDS
    CCDS31249.1
    UniProtKB/Swiss-Prot
    P02753
    Related
    ENSP00000360522.1, ENST00000371467.5
    Conserved Domains (1) summary
    pfam00061
    Location:39177
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
  2. NM_001323518.1NP_001310447.1  retinol-binding protein 4 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL356214, BC020633, BG565176, BI712834
    Consensus CDS
    CCDS81488.1
    UniProtKB/Swiss-Prot
    P02753
    UniProtKB/TrEMBL
    Q5VY30
    Related
    ENSP00000360524.2, ENST00000371469.2
    Conserved Domains (1) summary
    pfam00061
    Location:37175
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
  3. NM_006744.4NP_006735.2  retinol-binding protein 4 isoform a precursor

    See identical proteins and their annotated locations for NP_006735.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 both encode isoform a.
    Source sequence(s)
    AL356214, BC020633, BX495987, X00129
    Consensus CDS
    CCDS31249.1
    UniProtKB/Swiss-Prot
    P02753
    Related
    ENSP00000360519.3, ENST00000371464.8
    Conserved Domains (1) summary
    pfam00061
    Location:39177
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    93591694..93601744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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