U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rbp4 retinol binding protein 4, plasma [ Mus musculus (house mouse) ]

Gene ID: 19662, updated on 18-Apr-2024

Summary

Official Symbol
Rbp4provided by MGI
Official Full Name
retinol binding protein 4, plasmaprovided by MGI
Primary source
MGI:MGI:97879
See related
Ensembl:ENSMUSG00000024990 AllianceGenome:MGI:97879
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rbp-4
Summary
Enables retinol binding activity. Involved in several processes, including animal organ development; gluconeogenesis; and negative regulation of cardiac muscle cell proliferation. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; retinoid metabolic process; and terpenoid transport. Located in extracellular space. Is expressed in several structures, including adipose tissue; brain; genitourinary system; gut; and hindlimb. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 1256.0), liver E18 (RPKM 733.2) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
19 C2; 19 32.75 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (38105068..38113769, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (38116620..38125321, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 55 Neighboring gene predicted gene, 23300 Neighboring gene free fatty acid receptor 4 Neighboring gene predicted gene, 32440 Neighboring gene phosphodiesterase 6C, cGMP specific, cone, alpha prime Neighboring gene predicted gene, 52398

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables retinal binding IEA
Inferred from Electronic Annotation
more info
 
enables retinoid binding IEA
Inferred from Electronic Annotation
more info
 
enables retinol binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables retinol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables retinol binding ISO
Inferred from Sequence Orthology
more info
 
enables retinol transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within detection of light stimulus involved in visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryo development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eye development ISO
Inferred from Sequence Orthology
more info
 
involved_in female genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart trabecula formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of gastrointestinal epithelium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of immunoglobulin production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to insulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retinal metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retinol metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in retinol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in retinol transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within retinol transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within retinol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinol transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in urinary bladder development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in uterus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vagina development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vitamin A import into cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
retinol-binding protein 4
Names
PRBP
RBP
plasma retinol-binding protein
retinol binding protein 4, cellular

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159487.1NP_001152959.1  retinol-binding protein 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC101774, AK008765, AW113115, BY769772
    Consensus CDS
    CCDS50430.1
    UniProtKB/TrEMBL
    H7BWY6
    Related
    ENSMUSP00000025951.7, ENSMUST00000025951.14
    Conserved Domains (1) summary
    cd00743
    Location:66236
    lipocalin_RBP_like; retinol-binding protein 4 and similar proteins
  2. NM_011255.3NP_035385.1  retinol-binding protein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_035385.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK008765, AW113115, BY112174
    Consensus CDS
    CCDS29784.1
    UniProtKB/Swiss-Prot
    P70357, Q00724, Q566I5
    UniProtKB/TrEMBL
    Q3TF08
    Related
    ENSMUSP00000107954.3, ENSMUST00000112335.4
    Conserved Domains (1) summary
    cd00743
    Location:22192
    lipocalin_RBP_like; retinol-binding protein 4 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    38105068..38113769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)