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RBMS2 RNA binding motif single stranded interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 5939, updated on 21-Dec-2019

Summary

Official Symbol
RBMS2provided by HGNC
Official Full Name
RNA binding motif single stranded interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:9909
See related
Ensembl:ENSG00000076067 MIM:602387
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCR3
Summary
The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 17.5), placenta (RPKM 15.2) and 23 other tissues See more
Orthologs

Genomic context

See RBMS2 in Genome Data Viewer
Location:
12q13.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56520406..56596193)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56915607..56994859)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SPRY domain containing 4 Neighboring gene glutaminase 2 Neighboring gene small nucleolar RNA, H/ACA box 105C Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 4 Neighboring gene RNA, U6 small nuclear 343, pseudogene Neighboring gene bromodomain adjacent to zinc finger domain 2A Neighboring gene Sharpr-MPRA regulatory region 9353 Neighboring gene ATP synthase F1 subunit beta Neighboring gene small nucleolar RNA, C/D box 59B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39093, FLJ40023, FLJ43262

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA processing TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding motif, single-stranded-interacting protein 2
Names
suppressor of CDC2 with RNA-binding motif 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002898.4NP_002889.1  RNA-binding motif, single-stranded-interacting protein 2

    See identical proteins and their annotated locations for NP_002889.1

    Status: REVIEWED

    Source sequence(s)
    AC090681, AC097104, BC027863, CF890834, DC382164
    Consensus CDS
    CCDS8923.1
    UniProtKB/Swiss-Prot
    Q15434
    Related
    ENSP00000262031.5, ENST00000262031.10
    Conserved Domains (2) summary
    cd12474
    Location:135220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:49134
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    56520406..56596193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449115.1XP_024304883.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X5

    Conserved Domains (2) summary
    cd12470
    Location:19104
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:105190
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  2. XM_024449117.1XP_024304885.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X13

    Conserved Domains (2) summary
    cd12474
    Location:105190
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:19104
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_011538638.3XP_011536940.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X6

    Conserved Domains (2) summary
    cd12474
    Location:88173
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:3287
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_011538640.3XP_011536942.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X10

    See identical proteins and their annotated locations for XP_011536942.1

    UniProtKB/Swiss-Prot
    Q15434
    Conserved Domains (2) summary
    cd12474
    Location:135220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:49134
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_006719543.4XP_006719606.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X7

    Conserved Domains (2) summary
    cd12474
    Location:135220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:49134
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. XM_005269059.5XP_005269116.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X3

    Conserved Domains (2) summary
    cd12470
    Location:49134
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:135220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  7. XM_006719541.4XP_006719604.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X1

    Conserved Domains (2) summary
    cd12470
    Location:49134
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:135220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  8. XM_005269060.5XP_005269117.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X8

    Conserved Domains (2) summary
    cd12470
    Location:49134
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:135220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  9. XM_006719542.4XP_006719605.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X4

    Conserved Domains (2) summary
    cd12470
    Location:49134
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:135220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  10. XM_006719544.4XP_006719607.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X10

    See identical proteins and their annotated locations for XP_006719607.1

    UniProtKB/Swiss-Prot
    Q15434
    Related
    ENSP00000447426.1, ENST00000552247.6
    Conserved Domains (2) summary
    cd12474
    Location:135220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:49134
    RRM_SF; RNA recognition motif (RRM) superfamily
  11. XM_005269061.3XP_005269118.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X12

    Conserved Domains (2) summary
    cd12474
    Location:135220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:49134
    RRM_SF; RNA recognition motif (RRM) superfamily
  12. XM_011538639.2XP_011536941.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X9

    Conserved Domains (2) summary
    cd12474
    Location:135220
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:49134
    RRM_SF; RNA recognition motif (RRM) superfamily
  13. XM_005269066.4XP_005269123.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X17

    Conserved Domains (1) summary
    cl17169
    Location:49134
    RRM_SF; RNA recognition motif (RRM) superfamily
  14. XM_011538637.3XP_011536939.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X2

    Conserved Domains (2) summary
    cd12470
    Location:30115
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:116201
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  15. XM_017019775.2XP_016875264.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X11

  16. XM_024449116.1XP_024304884.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X5

    Conserved Domains (2) summary
    cd12470
    Location:19104
    RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1
    cd12474
    Location:105190
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  17. XM_017019777.2XP_016875266.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X15

  18. XM_011538642.3XP_011536944.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X14

    See identical proteins and their annotated locations for XP_011536944.1

    Conserved Domains (1) summary
    cd12474
    Location:1095
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
  19. XM_017019778.2XP_016875267.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X16

    Related
    ENSP00000443486.1, ENST00000542360.1

RNA

  1. XR_002957368.1 RNA Sequence

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