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Nek7 NIMA (never in mitosis gene a)-related expressed kinase 7 [ Mus musculus (house mouse) ]

Gene ID: 59125, updated on 2-Nov-2024

Summary

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Official Symbol
Nek7provided by MGI
Official Full Name
NIMA (never in mitosis gene a)-related expressed kinase 7provided by MGI
Primary source
MGI:MGI:1890645
See related
Ensembl:ENSMUSG00000026393 AllianceGenome:MGI:1890645
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810460C19Rik
Summary
Enables molecular function activator activity. Involved in cellular response to potassium ion and positive regulation of NLRP3 inflammasome complex assembly. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human NEK7 (NIMA related kinase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 17.1), heart adult (RPKM 10.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Nek7 in Genome Data Viewer
Location:
1 E4; 1 60.82 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (138411575..138547481, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (138483837..138619757, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10043 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:140196154-140196408 Neighboring gene STARR-positive B cell enhancer ABC_E3308 Neighboring gene predicted gene 28500 Neighboring gene STARR-seq mESC enhancer starr_02464 Neighboring gene STARR-positive B cell enhancer mm9_chr1:140511140-140511441 Neighboring gene STARR-positive B cell enhancer mm9_chr1:140513485-140513785 Neighboring gene STARR-positive B cell enhancer mm9_chr1:140514282-140514583 Neighboring gene STARR-positive B cell enhancer ABC_E1563 Neighboring gene STARR-seq mESC enhancer starr_02465 Neighboring gene predicted gene 5833 Neighboring gene STARR-seq mESC enhancer starr_02466 Neighboring gene predicted gene 8790

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DNA repair mediated by endonuclease-independent LINE-1 retrotransposition. Morrish TA, et al. Nat Genet, 2002 Jun. PMID 12006980
  2. The Microtubule Regulator NEK7 Coordinates the Wiring of Cortical Parvalbumin Interneurons. Hinojosa AJ, et al. Cell Rep, 2018 Jul 31. PMID 30067978, Free PMC Article
  3. Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy. Salem H, et al. Oncogene, 2010 Jul 15. PMID 20473324
  4. Silencing of METTL3 inhibits m6A methylation of NEK7 to suppress pyrolysis in an HT-22 cell-based model of intracerebral hemorrhage. Hong L, et al. Brain Res, 2024 May 15. PMID 38408556
  5. A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation. Schmid-Burgk JL, et al. J Biol Chem, 2016 Jan 1. PMID 26553871, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing of METTL3 inhibits m6A methylation of NEK7 to suppress pyrolysis in an HT-22 cell-based model of intracerebral hemorrhage.
    Title: Silencing of METTL3 inhibits m6A methylation of NEK7 to suppress pyrolysis in an HT-22 cell-based model of intracerebral hemorrhage.
  2. ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
    Title: ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.
  3. MARCH5-dependent NLRP3 ubiquitination is required for mitochondrial NLRP3-NEK7 complex formation and NLRP3 inflammasome activation.
    Title: MARCH5-dependent NLRP3 ubiquitination is required for mitochondrial NLRP3-NEK7 complex formation and NLRP3 inflammasome activation.
  4. miR-181a-5p Inhibits Pyroptosis in Sepsis-Induced Acute Kidney Injury through Downregulation of NEK7.
    Title: miR-181a-5p Inhibits Pyroptosis in Sepsis-Induced Acute Kidney Injury through Downregulation of NEK7.
  5. Knockdown of NEK7 alleviates anterior cruciate ligament transection osteoarthritis (ACLT)-induced knee osteoarthritis in mice via inhibiting NLRP3 activation.
    Title: Knockdown of NEK7 alleviates anterior cruciate ligament transection osteoarthritis (ACLT)-induced knee osteoarthritis in mice via inhibiting NLRP3 activation.
  6. MicroRNA-200c-5p targets NIMA Related Kinase 7 (NEK7) to inhibit NOD-like receptor 3 (NLRP3) inflammasome activation, MODE-K cell pyroptosis, and inflammatory bowel disease in mice.
    Title: MicroRNA-200c-5p targets NIMA Related Kinase 7 (NEK7) to inhibit NOD-like receptor 3 (NLRP3) inflammasome activation, MODE-K cell pyroptosis, and inflammatory bowel disease in mice.
  7. A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6.
    Title: A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6.
  8. NIMA-related kinase 7 amplifies NLRP3 inflammasome pro-inflammatory signaling in microglia/macrophages and mice models of spinal cord injury.
    Title: NIMA-related kinase 7 amplifies NLRP3 inflammasome pro-inflammatory signaling in microglia/macrophages and mice models of spinal cord injury.
  9. NEK7 mediated assembly and activation of NLRP3 inflammasome downstream of potassium efflux in ventilator-induced lung injury.
    Title: NEK7 mediated assembly and activation of NLRP3 inflammasome downstream of potassium efflux in ventilator-induced lung injury.
  10. NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-kappaB signaling.
    Title: NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (5) 
  • Gene trapped (3) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular function activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to potassium ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NLRP3 inflammasome complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek7
Names
NIMA-related expressed kinase 7
NIMA-related kinase 7
never in mitosis A-related kinase 7
nimA-related protein kinase 7
NP_001298077.1
NP_067618.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311148.2 → NP_001298077.1  serine/threonine-protein kinase Nek7 isoform 2

    See identical proteins and their annotated locations for NP_001298077.1

    Status: VALIDATED

    Source sequence(s)
    AC118216, AC161436
    Consensus CDS
    CCDS78695.1
    UniProtKB/TrEMBL
    Q3TN15
    Related
    ENSMUSP00000027642.4, ENSMUST00000027642.5
    Conserved Domains (1) summary
    cl21453
    Location:9 → 199
    PKc_like; Protein Kinases, catalytic domain

  2. NM_021605.5 → NP_067618.1  serine/threonine-protein kinase Nek7 isoform 1

    See identical proteins and their annotated locations for NP_067618.1

    Status: VALIDATED

    Source sequence(s)
    AC118216, AC161436
    Consensus CDS
    CCDS15332.1
    UniProtKB/Swiss-Prot
    Q3UEV7, Q9ES74
    Related
    ENSMUSP00000140903.3, ENSMUST00000186017.7
    Conserved Domains (2) summary
    smart00220
    Location:34 → 286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08224
    Location:33 → 294
    STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    138411575..138547481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ES74.1 GenPept UniProtKB/Swiss-Prot:Q9ES74

Gene LinkOut

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