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NEK7 NIMA related kinase 7 [ Homo sapiens (human) ]

Gene ID: 140609, updated on 9-Feb-2020

Summary

Official Symbol
NEK7provided by HGNC
Official Full Name
NIMA related kinase 7provided by HGNC
Primary source
HGNC:HGNC:13386
See related
Ensembl:ENSG00000151414 MIM:606848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]
Expression
Ubiquitous expression in heart (RPKM 38.5), fat (RPKM 31.8) and 24 other tissues See more
Orthologs

Genomic context

See NEK7 in Genome Data Viewer
Location:
1q31.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (198156998..198322420)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (198126108..198291550)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 53 Neighboring gene LIM homeobox 9 Neighboring gene proline rich 13 pseudogene 1 Neighboring gene VISTA enhancer hs1322 Neighboring gene uncharacterized LOC105371677 Neighboring gene ATPase H+ transporting V1 subunit G3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
spindle assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Nek7
Names
NIMA (never in mitosis gene a)-related kinase 7
never in mitosis A-related kinase 7
nimA-related protein kinase 7
NP_598001.1
XP_011507511.1
XP_016855833.1
XP_016855834.1
XP_016855835.1
XP_016855836.1
XP_016855837.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133494.3NP_598001.1  serine/threonine-protein kinase Nek7

    See identical proteins and their annotated locations for NP_598001.1

    Status: VALIDATED

    Source sequence(s)
    AC093419, AK313411, DB498485
    Consensus CDS
    CCDS1394.1
    UniProtKB/Swiss-Prot
    Q8TDX7
    UniProtKB/TrEMBL
    A0A024R964, B2R8K8
    Related
    ENSP00000356355.4, ENST00000367385.9
    Conserved Domains (1) summary
    cd08224
    Location:33294
    STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    198156998..198322420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000344.1XP_016855833.1  serine/threonine-protein kinase Nek7 isoform X1

  2. XM_017000346.1XP_016855835.1  serine/threonine-protein kinase Nek7 isoform X2

  3. XM_011509209.1XP_011507511.1  serine/threonine-protein kinase Nek7 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:9158
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017000347.1XP_016855836.1  serine/threonine-protein kinase Nek7 isoform X3

  5. XM_017000348.1XP_016855837.1  serine/threonine-protein kinase Nek7 isoform X3

  6. XM_017000345.1XP_016855834.1  serine/threonine-protein kinase Nek7 isoform X1

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