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RAP2B RAP2B, member of RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 5912, updated on 17-Jun-2019

Summary

Official Symbol
RAP2Bprovided by HGNC
Official Full Name
RAP2B, member of RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9862
See related
Ensembl:ENSG00000181467 MIM:179541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See RAP2B in Genome Data Viewer
Location:
3q25.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (153162226..153170627)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (152880001..152888413)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 13 Neighboring gene KIAA1328 pseudogene Neighboring gene uncharacterized LOC105374164 Neighboring gene RNA, 7SL, cytoplasmic 300, pseudogene Neighboring gene uncharacterized LOC105374166

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag Prostaglandin E2-mediated HIV-1 inhibition requires the EPAC/RAP/RhoA signaling pathway by downregulation of HIV-1 CA production PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20484

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Rap protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rap protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT microvillus assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
platelet activation IDA
Inferred from Direct Assay
more info
PubMed 
platelet aggregation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell contact zone IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane raft IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
recycling endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ras-related protein Rap-2b
Names
small GTP binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002886.4NP_002877.2  ras-related protein Rap-2b

    See identical proteins and their annotated locations for NP_002877.2

    Status: REVIEWED

    Source sequence(s)
    AC117394, AI718675, AW997098, BC012362, BI551390, BQ378964, BU507815, BU860799, BX116683, CB116910, HY071303
    Consensus CDS
    CCDS3170.1
    UniProtKB/Swiss-Prot
    P61225
    Related
    ENSP00000319096.2, ENST00000323534.4
    Conserved Domains (1) summary
    cd04176
    Location:3165
    Rap2; Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    153162226..153170627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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