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IL22RA1 interleukin 22 receptor subunit alpha 1 [ Homo sapiens (human) ]

Gene ID: 58985, updated on 2-Nov-2024

Summary

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Official Symbol
IL22RA1provided by HGNC
Official Full Name
interleukin 22 receptor subunit alpha 1provided by HGNC
Primary source
HGNC:HGNC:13700
See related
Ensembl:ENSG00000142677 MIM:605457; AllianceGenome:HGNC:13700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL22R; CRF2-9; IL22R1
Summary
The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]
Expression
Biased expression in pancreas (RPKM 15.5), skin (RPKM 14.3) and 9 other tissues See more
Orthologs
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Genomic context

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See IL22RA1 in Genome Data Viewer
Location:
1p36.11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (24119771..24143140, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23957480..23980846, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24446261..24469630, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene myomesin 3 Neighboring gene uncharacterized LOC124903878 Neighboring gene uncharacterized LOC105376864 Neighboring gene Sharpr-MPRA regulatory region 3135 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24433598-24434138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24438827-24439335 Neighboring gene Sharpr-MPRA regulatory region 13639 Neighboring gene uncharacterized LOC124903879 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24479387-24479984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24479985-24480582 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:24480583-24481180 Neighboring gene interferon lambda receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 391 Neighboring gene long intergenic non-protein coding RNA 2800

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Change of IL-22R1 expression in human airway smooth muscle cells in response to different stimulating agents]. Zhang Z, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2011 Jun. PMID 21690049
  2. Interleukin-22 receptor is overexpressed in nonsmall cell lung cancer and portends a poor prognosis. Guillon A, et al. Eur Respir J, 2016 Apr. PMID 26846835
  3. IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression. Tohyama M, et al. Eur J Immunol, 2009 Oct. PMID 19731362
  4. Interleukin 22 receptor 1 expression in pancreas islets. Shioya M, et al. Pancreas, 2008 Mar. PMID 18376313
  5. IL-22Ra1 is induced during influenza infection by direct and indirect TLR3 induction of STAT1. Hebert KD, et al. Respir Res, 2019 Aug 15. PMID 31416461, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis.
    Title: Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis.
  2. Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
    Title: Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
  3. Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis.
    Title: Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis.
  4. Lack of Association of Polymorphisms in IL22 and IL22RA1 Genes with Fibrosis Severity in Patients with Chronic Hepatitis C.
    Title: Lack of Association of Polymorphisms in IL22 and IL22RA1 Genes with Fibrosis Severity in Patients with Chronic Hepatitis C.
  5. Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection.
    Title: Distinct Expression Patterns of Interleukin-22 Receptor 1 on Blood Hematopoietic Cells in SARS-CoV-2 Infection.
  6. Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages.
    Title: Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages.
  7. Increased expression of interleukin-22 and its receptor is relevant to poor prognosis in laryngeal squamous cell carcinoma: A case control trial.
    Title: Increased expression of interleukin-22 and its receptor is relevant to poor prognosis in laryngeal squamous cell carcinoma: A case control trial.
  8. Targeting IL-22 and IL-22R protects against experimental osteoarthritis.
    Title: Targeting IL-22 and IL-22R protects against experimental osteoarthritis.
  9. High IL-22RA1 gene expression is associated with poor outcome in muscle invasive bladder cancer.
    Title: High IL-22RA1 gene expression is associated with poor outcome in muscle invasive bladder cancer.
  10. Association of interleukin 22 receptor subunit alpha 1 gene polymorphisms with chronic rhinosinusitis.
    Title: Association of interleukin 22 receptor subunit alpha 1 gene polymorphisms with chronic rhinosinusitis.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of interleukin 22 receptor, alpha 1 (IL22RA1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interferon receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables interleukin-20 binding IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-22 receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-22-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
interleukin-22 receptor subunit alpha-1
Names
IL-22 receptor subunit alpha-1
IL-22R-alpha-1
IL-22RA1
cytokine receptor class-II member 9
cytokine receptor family 2 member 9
interleukin 22 receptor, alpha 1
zcytoR11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021258.4 → NP_067081.2  interleukin-22 receptor subunit alpha-1 precursor

    See identical proteins and their annotated locations for NP_067081.2

    Status: REVIEWED

    Source sequence(s)
    AK313971, BC029273
    Consensus CDS
    CCDS247.1
    UniProtKB/Swiss-Prot
    A8K839, B2R9Y9, Q8N6P7, Q9HB22
    UniProtKB/TrEMBL
    B4E2V9
    Related
    ENSP00000270800.1, ENST00000270800.2
    Conserved Domains (3) summary
    PHA03247
    Location:305 → 529
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:293 → 401
    PRK10263; DNA translocase FtsK; Provisional
    pfam01108
    Location:4 → 107
    Tissue_fac; Tissue factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    24119771..24143140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    23957480..23980846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N6P7.1 GenPept UniProtKB/Swiss-Prot:Q8N6P7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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