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IL22RA1 interleukin 22 receptor subunit alpha 1 [ Homo sapiens (human) ]

Gene ID: 58985, updated on 13-Mar-2020

Summary

Official Symbol
IL22RA1provided by HGNC
Official Full Name
interleukin 22 receptor subunit alpha 1provided by HGNC
Primary source
HGNC:HGNC:13700
See related
Ensembl:ENSG00000142677 MIM:605457
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL22R; CRF2-9; IL22R1
Summary
The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]
Expression
Biased expression in pancreas (RPKM 15.5), skin (RPKM 14.3) and 9 other tissues See more
Orthologs

Genomic context

See IL22RA1 in Genome Data Viewer
Location:
1p36.11
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (24119771..24143179, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24446261..24469783, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene myomesin 3 Neighboring gene MYOM3 antisense RNA 1 Neighboring gene uncharacterized LOC105376864 Neighboring gene interferon lambda receptor 1 Neighboring gene long intergenic non-protein coding RNA 2800

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of interleukin 22 receptor, alpha 1 (IL22RA1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interferon receptor activity TAS
Traceable Author Statement
more info
PubMed 
interleukin-20 binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to Gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-22 receptor subunit alpha-1
Names
IL-22 receptor subunit alpha-1
IL-22R-alpha-1
IL-22RA1
cytokine receptor class-II member 9
cytokine receptor family 2 member 9
interleukin 22 receptor, alpha 1
zcytoR11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021258.4NP_067081.2  interleukin-22 receptor subunit alpha-1 precursor

    See identical proteins and their annotated locations for NP_067081.2

    Status: REVIEWED

    Source sequence(s)
    AK313971, BC029273
    Consensus CDS
    CCDS247.1
    UniProtKB/Swiss-Prot
    Q8N6P7
    Related
    ENSP00000270800.1, ENST00000270800.2
    Conserved Domains (3) summary
    pfam01108
    Location:26107
    Tissue_fac; Tissue factor
    cl21522
    Location:119214
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl26464
    Location:289557
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    24119771..24143179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541882.1XP_011540184.1  interleukin-22 receptor subunit alpha-1 isoform X1

    Conserved Domains (1) summary
    PHA03160
    Location:197297
    PHA03160; hypothetical protein; Provisional
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