Il22ra1 interleukin 22 receptor, alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il22ra1provided by MGI
Official Full Name: interleukin 22 receptor, alpha 1provided by MGI
Primary source: MGI:MGI:2663588
See related: Ensembl:ENSMUSG00000037157 AllianceGenome:MGI:2663588
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il22r; IL-22R; 9130219A07Rik
Summary: Enables interleukin-20 binding activity. Acts upstream of or within defense response to Gram-negative bacterium. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human IL22RA1 (interleukin 22 receptor subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in small intestine adult (RPKM 29.4), large intestine adult (RPKM 23.2) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 67.99 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (135455470..135482694)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (135728159..135755383)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin-22 receptor 1 (IL22R1) and interleukin-22 are upregulated after hindlimb ischemia.
Title: Interleukin-22 receptor 1 upregulation and activation in hypoxic endothelial cells improves perfusion recovery in experimental peripheral arterial disease.
Endogenous IL-22 and hepatic IL-22R signaling play critical roles in controlling pneumococcal lung burden, and systemic IL-22 decreases bacterial burden in the lungs and peripheral organs by potentiating C3 opsonization on bacterial surfaces, through the increase of hepatic C3 expression.
Title: Critical Role of IL-22/IL22-RA1 Signaling in Pneumococcal Pneumonia.
our data suggest that IL-20 subfamily cytokines, particularly IL-20, IL-22, and IL-24, might provide therapeutic benefit for patients with Diabetic foot ulcers (DFU) .
Title: IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice.
IL-22 and its receptor have a crucial role in the development and pathogenesis of uveitis by facilitating inflammatory cell infiltration.
Title: The Role of Interleukin-22 and Its Receptor in the Development and Pathogenesis of Experimental Autoimmune Uveitis.
this study shows that IL-22 plays role in acute graft versus host disease via IL-22R-STAT3 pathway
Title: IL-22 promoted CD3+ T cell infiltration by IL-22R induced STAT3 phosphorylation in murine acute graft versus host disease target organs after allogeneic bone marrow transplantation.
RNA sequencing analyses of primary colonic organoids showed that IL-22RA1 signaling promotes intestinal fucosylation via induction of the fucosyltransferase Fut2.
Title: Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen.
These findings reveal the ability of GSK-3beta to modulate IL-22R protein stability that might have significant implications for cytoprotective functions and therapeutic targeting of the IL-22 signaling axis.
Title: Glycogen synthase kinase-3β stabilizes the interleukin (IL)-22 receptor from proteasomal degradation in murine lung epithelia.
IL-22R was up-regulated in lymphoid organs and joints during the course of arthritis.
Title: Interleukin-22 reduces the severity of collagen-induced arthritis in association with increased levels of interleukin-10.
This study documents a previously unknown role of IL-22R1 in inflammation and identifies the involvement of IL-22R1/IL-22 in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
Title: A novel role for IL-22R1 as a driver of inflammation.
Genomic structure and inducible expression of the IL-22 receptor alpha chain.
Title: Genomic structure and inducible expression of the IL-22 receptor alpha chain in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

D4Mit134 (e-PCR), detects polymorphism
- UniSTS:129909

Homology

Homologs of the Il22ra1 gene: The Il22ra1 gene is conserved in human, chimpanzee, dog, cow, rat, and chicken.
Orthologs from Annotation Pipeline: 340 organisms have orthologs with human gene Il22ra1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables interleukin-20 binding	IPI Inferred from Physical Interaction more info	PubMed
enables interleukin-22 receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: interleukin-22 receptor subunit alpha-1

Names: IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; interleukin-22 receptor alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178257.2 → NP_839988.1 interleukin-22 receptor subunit alpha-1 precursor

Status: VALIDATED

Source sequence(s)

AK141289, AK162333, AL662911

Consensus CDS

CCDS18789.1

UniProtKB/Swiss-Prot

Q3URP9, Q80XZ4

UniProtKB/TrEMBL

Q3TS18

Related

ENSMUSP00000099605.4, ENSMUST00000102546.4

Conserved Domains (2) summary

pfam01108
Location:26 → 107

Tissue_fac; Tissue factor

pfam17037
Location:287 → 374

CBP_BcsO; Cellulose biosynthesis protein BcsO