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MOK MOK protein kinase [ Homo sapiens (human) ]

Gene ID: 5891, updated on 12-Oct-2019

Summary

Official Symbol
MOKprovided by HGNC
Official Full Name
MOK protein kinaseprovided by HGNC
Primary source
HGNC:HGNC:9833
See related
Ensembl:ENSG00000080823 MIM:605762
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAGE; RAGE1; STK30; RAGE-1
Summary
This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Expression
Broad expression in testis (RPKM 9.4), thyroid (RPKM 2.1) and 15 other tissues See more
Orthologs

Genomic context

See MOK in Genome Data Viewer
Location:
14q32.31
Exon count:
23
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (102224441..102305191, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102690834..102771537, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene heat shock protein 90 alpha family class A member 1 Neighboring gene WD repeat domain 20 Neighboring gene uncharacterized LOC105370677 Neighboring gene tRNA-Ile (anticodon AAT) 5-4 Neighboring gene zinc finger protein 839

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16778

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
ciliary base ISS
Inferred from Sequence or Structural Similarity
more info
 
cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
MAPK/MAK/MRK overlapping kinase
Names
renal cell carcinoma antigen
renal tumor antigen 1
NP_001258940.1
NP_001317163.1
NP_001340756.1
NP_001340757.1
NP_001340758.1
NP_001340759.1
NP_001340760.1
NP_001340761.1
NP_055041.1
XP_006720288.1
XP_006720289.1
XP_011535354.1
XP_011535355.1
XP_016877041.1
XP_016877044.1
XP_016877045.1
XP_016877046.1
XP_016877047.1
XP_024305449.1
XP_024305450.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272011.2NP_001258940.1  MAPK/MAK/MRK overlapping kinase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB022694, AK302349, AL359402, DB517173
    Consensus CDS
    CCDS61552.1
    UniProtKB/Swiss-Prot
    Q9UQ07
    Related
    ENSP00000428942.1, ENST00000524214.5
    Conserved Domains (2) summary
    smart00220
    Location:4255
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07831
    Location:4255
    STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase
  2. NM_001330234.2NP_001317163.1  MAPK/MAK/MRK overlapping kinase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402, DB517173
    Consensus CDS
    CCDS81854.1
    UniProtKB/Swiss-Prot
    Q9UQ07
    Related
    ENSP00000429469.1, ENST00000522874.5
  3. NM_001353827.2NP_001340756.1  MAPK/MAK/MRK overlapping kinase isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402
    Conserved Domains (1) summary
    cd07831
    Location:4254
    STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase
  4. NM_001353828.2NP_001340757.1  MAPK/MAK/MRK overlapping kinase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402
    Conserved Domains (1) summary
    cl21453
    Location:1221
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001353829.2NP_001340758.1  MAPK/MAK/MRK overlapping kinase isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402
    Conserved Domains (1) summary
    cl21453
    Location:1180
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001353830.2NP_001340759.1  MAPK/MAK/MRK overlapping kinase isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402
    Conserved Domains (1) summary
    cl21453
    Location:1179
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001353831.2NP_001340760.1  MAPK/MAK/MRK overlapping kinase isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402
    Conserved Domains (1) summary
    cl21453
    Location:1103
    PKc_like; Protein Kinases, catalytic domain
  8. NM_001353832.2NP_001340761.1  MAPK/MAK/MRK overlapping kinase isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402
    Conserved Domains (2) summary
    COG0515
    Location:2135
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cl21453
    Location:151
    PKc_like; Protein Kinases, catalytic domain
  9. NM_014226.3NP_055041.1  MAPK/MAK/MRK overlapping kinase isoform 1

    See identical proteins and their annotated locations for NP_055041.1

    Status: REVIEWED

    Source sequence(s)
    AB022694, DB037795, DB517173
    Consensus CDS
    CCDS9971.1
    UniProtKB/Swiss-Prot
    Q9UQ07
    Related
    ENSP00000355304.2, ENST00000361847.7
    Conserved Domains (2) summary
    smart00220
    Location:4285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07831
    Location:4285
    STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

RNA

  1. NR_073540.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI932404, AL359402, U46193, U46194
    Related
    ENST00000559138.5
  2. NR_073541.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    U46193
    Related
    ENST00000517966.5
  3. NR_073542.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' exon structure and lacks an internal exon compared to variant 1. This variant is represented as non-coding because the longest open reading frame is in a different frame compared to variant 1, and there is no support for the predicted protein encoded by this ORF.
    Source sequence(s)
    DB517173, U46192, U46193
    Related
    ENST00000524370.5
  4. NR_073543.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BG184866, DB517173, U46191, U46193
    Related
    ENST00000523231.5
  5. NR_148552.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402
  6. NR_148553.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI932404, AL352978, AL359402
  7. NR_148554.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI932404, AL352978, AL359402
  8. NR_148555.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI932404, AL352978, AL359402
  9. NR_148556.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI932404, AL352978, AL359402

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    102224441..102305191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021555.2XP_016877044.1  MAPK/MAK/MRK overlapping kinase isoform X6

  2. XM_006720225.3XP_006720288.1  MAPK/MAK/MRK overlapping kinase isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:4285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07831
    Location:4285
    STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase
  3. XM_011537052.2XP_011535354.1  MAPK/MAK/MRK overlapping kinase isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:4285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07831
    Location:4285
    STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase
  4. XM_017021556.2XP_016877045.1  MAPK/MAK/MRK overlapping kinase isoform X7

  5. XM_006720226.3XP_006720289.1  MAPK/MAK/MRK overlapping kinase isoform X5

    Conserved Domains (2) summary
    smart00220
    Location:4285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07831
    Location:4285
    STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase
  6. XM_024449682.1XP_024305450.1  MAPK/MAK/MRK overlapping kinase isoform X11

  7. XM_011537053.3XP_011535355.1  MAPK/MAK/MRK overlapping kinase isoform X10

    Conserved Domains (2) summary
    COG0515
    Location:85218
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cl21453
    Location:47134
    PKc_like; Protein Kinases, catalytic domain
  8. XM_017021557.2XP_016877046.1  MAPK/MAK/MRK overlapping kinase isoform X8

  9. XM_024449681.1XP_024305449.1  MAPK/MAK/MRK overlapping kinase isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:8221
    PKc_like; Protein Kinases, catalytic domain
  10. XM_017021558.1XP_016877047.1  MAPK/MAK/MRK overlapping kinase isoform X9

  11. XM_017021552.1XP_016877041.1  MAPK/MAK/MRK overlapping kinase isoform X3

RNA

  1. XR_001750492.2 RNA Sequence

  2. XR_429323.3 RNA Sequence

  3. XR_429320.3 RNA Sequence

  4. XR_429322.3 RNA Sequence

    Related
    ENST00000519569.5
  5. XR_943504.2 RNA Sequence

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