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RABGGTB Rab geranylgeranyltransferase subunit beta [ Homo sapiens (human) ]

Gene ID: 5876, updated on 21-Dec-2019

Summary

Official Symbol
RABGGTBprovided by HGNC
Official Full Name
Rab geranylgeranyltransferase subunit betaprovided by HGNC
Primary source
HGNC:HGNC:9796
See related
Ensembl:ENSG00000137955 MIM:179080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GGTB
Summary
This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in adrenal (RPKM 28.6), kidney (RPKM 27.1) and 25 other tissues See more
Orthologs

Genomic context

See RABGGTB in Genome Data Viewer
Location:
1p31.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (75786194..75795090)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (76251879..76260775)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 44 member 5 Neighboring gene diphosphoinositol pentakisphosphate kinase 2 pseudogene Neighboring gene acyl-CoA dehydrogenase medium chain Neighboring gene dihydrolipoamide S-succinyltransferase pseudogene 1 Neighboring gene small nucleolar RNA, C/D box 45C Neighboring gene small nucleolar RNA, C/D box 45A Neighboring gene small nucleolar RNA, C/D box 45B Neighboring gene mutS homolog 4 Neighboring gene ankyrin repeat and SOCS box containing 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45262

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to Rab geranylgeranyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab geranylgeranyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cellular protein modification process NAS
Non-traceable Author Statement
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein geranylgeranylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein geranylgeranylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein prenylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process TAS
Traceable Author Statement
more info
 
visual perception TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Rab-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab-protein geranylgeranyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
geranylgeranyl transferase type-2 subunit beta
Names
GGTase-II-beta
Rab geranylgeranyltransferase beta subunit
rab GG transferase beta
rab GGTase beta
type II protein geranyl-geranyltransferase subunit beta
NP_004573.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004582.4NP_004573.2  geranylgeranyl transferase type-2 subunit beta

    See identical proteins and their annotated locations for NP_004573.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the supported protein.
    Source sequence(s)
    AL357314, BC020790, BQ773824
    Consensus CDS
    CCDS669.1
    UniProtKB/Swiss-Prot
    P53611
    UniProtKB/TrEMBL
    A8KAJ2, Q6IB63
    Related
    ENSP00000317473.3, ENST00000319942.8
    Conserved Domains (1) summary
    cd02894
    Location:18301
    GGTase-II; Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying ...

RNA

  1. NR_073562.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK293057, AL357314, BC020790, BQ773824

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    75786194..75795090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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