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Rabggtb Rab geranylgeranyl transferase, b subunit [ Mus musculus (house mouse) ]

Gene ID: 19352, updated on 8-Dec-2022

Summary

Official Symbol
Rabggtbprovided by MGI
Official Full Name
Rab geranylgeranyl transferase, b subunitprovided by MGI
Primary source
MGI:MGI:99537
See related
Ensembl:ENSMUSG00000038975 AllianceGenome:MGI:99537
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable isoprenoid binding activity; small GTPase binding activity; and zinc ion binding activity. Predicted to contribute to Rab geranylgeranyltransferase activity. Predicted to be involved in protein geranylgeranylation. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Is expressed in several structures, including central nervous system; genitourinary system; liver; stomach; and thymus. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 39.6), liver E14.5 (RPKM 35.5) and 25 other tissues See more
Orthologs
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Genomic context

See Rabggtb in Genome Data Viewer
Location:
3 H3; 3 78.76 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (153612926..153618603, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (153907289..153912966, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 17, opposite strand Neighboring gene ankyrin repeat and SOCS box-containing 17 Neighboring gene predicted gene, 24395 Neighboring gene mutS homolog 4 Neighboring gene small nucleolar RNA, C/D box 45B Neighboring gene small nucleolar RNA, C/D box 45C Neighboring gene predicted gene, 24494 Neighboring gene acyl-Coenzyme A dehydrogenase, medium chain Neighboring gene solute carrier family 44, member 5 Neighboring gene predicted gene, 40185

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to Rab geranylgeranyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Rab geranylgeranyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables isoprenoid binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein geranylgeranylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein geranylgeranylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Rab-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Rab-protein geranylgeranyltransferase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
geranylgeranyl transferase type-2 subunit beta
Names
GGTase-II-beta
RAB geranylgeranyltransferase, beta subunit
geranylgeranyl transferase type II subunit beta
rab GG transferase beta
rab GGTase beta
rab geranyl-geranyltransferase subunit beta
type II protein geranyl-geranyltransferase subunit beta
NP_001156950.1
NP_001156951.1
NP_035361.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163478.1NP_001156950.1  geranylgeranyl transferase type-2 subunit beta isoform 2

    See identical proteins and their annotated locations for NP_001156950.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK160162, CX205055
    Consensus CDS
    CCDS51097.1
    UniProtKB/TrEMBL
    A0A6P5PF62, Q3TVF4
    Related
    ENSMUSP00000087396.5, ENSMUST00000089950.11
    Conserved Domains (1) summary
    cd02894
    Location:18301
    GGTase-II; Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying ...
  2. NM_001163479.1NP_001156951.1  geranylgeranyl transferase type-2 subunit beta isoform 3

    See identical proteins and their annotated locations for NP_001156951.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC087184, AK160162, CN456589
    UniProtKB/TrEMBL
    Q3TVF4
    Conserved Domains (1) summary
    cd02894
    Location:1261
    GGTase-II; Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying ...
  3. NM_011231.2NP_035361.2  geranylgeranyl transferase type-2 subunit beta isoform 1

    See identical proteins and their annotated locations for NP_035361.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK160162, BC132473, BX512972
    Consensus CDS
    CCDS17923.1
    UniProtKB/Swiss-Prot
    A2RTE6, P53612
    UniProtKB/TrEMBL
    Q3TVF4
    Related
    ENSMUSP00000129481.2, ENSMUST00000167111.6
    Conserved Domains (2) summary
    PLN03201
    Location:22331
    PLN03201; RAB geranylgeranyl transferase beta-subunit; Provisional
    cd02894
    Location:26309
    GGTase-II; Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying ...

RNA

  1. NR_028094.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' end, uses an alternate internal splice junction, and has an alternate internal exon compared to variant 1. The internal alternate exon contains an in-frame termination codon, making this transcript a nonsense-mediated mRNA decay (NMD) candidate. Therefore, this transcript is not thought to be protein-coding.
    Source sequence(s)
    AK160162, CF732295, CX205055
    Related
    ENSMUST00000198350.5
  2. NR_028095.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate internal splice junction and has an alternate internal exon compared to variant 1. The internal alternate exon contains an in-frame termination codon, making this transcript a nonsense-mediated mRNA decay (NMD) candidate. Therefore, this transcript is not thought to be protein-coding.
    Source sequence(s)
    AF231926, AK160162, BX512972
    Related
    ENSMUST00000196266.5
  3. NR_028096.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has an alternate internal exon compared to variant 1. The internal alternate exon contains an in-frame termination codon, making this transcript a nonsense-mediated mRNA decay (NMD) candidate. Therefore, this transcript is not thought to be protein-coding.
    Source sequence(s)
    AK160162, BC145325, BX512972
  4. NR_028097.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' end, uses an alternate internal splice junction, and has an alternate internal exon compared to variant 1. The internal alternate exon contains an in-frame termination codon, making this transcript a nonsense-mediated mRNA decay (NMD) candidate. Therefore, this transcript is not thought to be protein-coding.
    Source sequence(s)
    AC087184, AK160162, CV562676
  5. NR_028098.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' end and uses an alternate internal splice junction compared to variant 1. The alternate internal splice junction causes a frameshift, making this transcript a nonsense-mediated mRNA decay (NMD) candidate. Therefore, this transcript is not thought to be protein-coding.
    Source sequence(s)
    AC087184, AK160162, BG076913

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    153612926..153618603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)