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RAB3A RAB3A, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 5864, updated on 7-Jun-2020

Summary

Official Symbol
RAB3Aprovided by HGNC
Official Full Name
RAB3A, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9777
See related
Ensembl:ENSG00000105649 MIM:179490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 78.9), heart (RPKM 7.0) and 1 other tissue See more
Orthologs

Genomic context

See RAB3A in Genome Data Viewer
Location:
19p13.11
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (18196784..18204042, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18307609..18314874, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene IFI30 lysosomal thiol reductase Neighboring gene MPV17 mitochondrial inner membrane protein like 2 Neighboring gene uncharacterized LOC102725254 Neighboring gene phosphodiesterase 4C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of RAB3A is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase activator activity IEA
Inferred from Electronic Annotation
more info
 
ATPase binding IEA
Inferred from Electronic Annotation
more info
 
GDP-dissociation inhibitor binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTP-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
myosin V binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acrosomal vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
constitutive secretory pathway TAS
Traceable Author Statement
more info
PubMed 
evoked neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
glutamate secretion TAS
Traceable Author Statement
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
lysosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of presynaptic active zone structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 
neuromuscular synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter secretion TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
plasma membrane repair IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ATPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of exocytosis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of regulated secretory pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulated exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dopamine secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of plasma membrane repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of short-term neuronal synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of synaptic vesicle fusion to presynaptic active zone membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic vesicle priming IEA
Inferred from Electronic Annotation
more info
 
respiratory system process IEA
Inferred from Electronic Annotation
more info
 
response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
sensory perception of touch IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle clustering IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle maturation IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle recycling ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle transport IEA
Inferred from Electronic Annotation
more info
 
vesicle docking involved in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
anchored component of synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
clathrin-sculpted acetylcholine transport vesicle membrane TAS
Traceable Author Statement
more info
 
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane TAS
Traceable Author Statement
more info
 
clathrin-sculpted glutamate transport vesicle membrane TAS
Traceable Author Statement
more info
 
clathrin-sculpted monoamine transport vesicle membrane TAS
Traceable Author Statement
more info
 
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular vesicle HDA PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
presynaptic active zone ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
terminal bouton ISS
Inferred from Sequence or Structural Similarity
more info
 
vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-3A
Names
RAS-associated protein RAB3A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002866.5NP_002857.1  ras-related protein Rab-3A

    See identical proteins and their annotated locations for NP_002857.1

    Status: VALIDATED

    Source sequence(s)
    AC068499, BC011782, BM717329, DB497194
    Consensus CDS
    CCDS12372.1
    UniProtKB/Swiss-Prot
    P20336
    UniProtKB/TrEMBL
    A0A024R7I7
    Related
    ENSP00000222256.3, ENST00000222256.9
    Conserved Domains (1) summary
    cd01865
    Location:22186
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    18196784..18204042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528164.2XP_011526466.1  ras-related protein Rab-3A isoform X1

    See identical proteins and their annotated locations for XP_011526466.1

    UniProtKB/Swiss-Prot
    P20336
    UniProtKB/TrEMBL
    A0A024R7I7
    Conserved Domains (1) summary
    cd01865
    Location:22186
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
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