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Rab3a RAB3A, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19339, updated on 6-Jun-2024

Summary

Official Symbol
Rab3aprovided by MGI
Official Full Name
RAB3A, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:97843
See related
Ensembl:ENSMUSG00000031840 AllianceGenome:MGI:97843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables GTP-dependent protein binding activity. Involved in several processes, including regulation of short-term neuronal synaptic plasticity; secretion by cell; and synaptic vesicle localization. Acts upstream of or within several processes, including chemical synaptic transmission; maintenance of presynaptic active zone structure; and synaptic vesicle maturation. Located in cytoplasmic vesicle; presynaptic active zone; and terminal bouton. Is anchored component of synaptic vesicle membrane. Is expressed in brain and inner ear. Orthologous to human RAB3A (RAB3A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 223.6), cortex adult (RPKM 207.3) and 13 other tissues See more
Orthologs
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Genomic context

See Rab3a in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71207258..71211276)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70754703..70758608)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34255 Neighboring gene predicted gene 3336 Neighboring gene phosphodiesterase 4C, cAMP specific Neighboring gene STARR-positive B cell enhancer ABC_E1370 Neighboring gene RIKEN cDNA 6330537M06 gene Neighboring gene STARR-positive B cell enhancer ABC_E190 Neighboring gene MPV17 mitochondrial membrane protein-like 2 Neighboring gene interferon gamma inducible protein 30

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables GDP-dissociation inhibitor binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables myosin V binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables myosin V binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in acrosomal vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium-ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium-ion regulated exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of localization in cell IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in evoked neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin secretion IPI
Inferred from Physical Interaction
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within maintenance of presynaptic active zone structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma membrane repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of regulated secretory pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulated exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of long-term synaptic potentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of plasma membrane repair ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of presynaptic dense core granule exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of presynaptic dense core granule exocytosis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of presynaptic dense core granule exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of short-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of synaptic vesicle fusion to presynaptic active zone membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within respiratory system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to electrical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of touch IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synaptic vesicle maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-sculpted glutamate transport vesicle membrane TAS
Traceable Author Statement
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle membrane IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166399.3NP_001159871.1  ras-related protein Rab-3A

    See identical proteins and their annotated locations for NP_001159871.1

    Status: VALIDATED

    Source sequence(s)
    CAAA01070179
    Consensus CDS
    CCDS22379.1
    UniProtKB/Swiss-Prot
    P05713, P63011, Q3TSL4
    UniProtKB/TrEMBL
    Q0PD63
    Related
    ENSMUSP00000105720.3, ENSMUST00000110093.9
    Conserved Domains (1) summary
    cd01865
    Location:22186
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
  2. NM_001328047.2NP_001314976.1  ras-related protein Rab-3A

    Status: VALIDATED

    Source sequence(s)
    CAAA01070179
    Consensus CDS
    CCDS22379.1
    UniProtKB/Swiss-Prot
    P05713, P63011, Q3TSL4
    UniProtKB/TrEMBL
    Q0PD63
    Related
    ENSMUSP00000105717.2, ENSMUST00000110090.8
    Conserved Domains (1) summary
    cd01865
    Location:22186
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
  3. NM_001378892.1NP_001365821.1  ras-related protein Rab-3A

    Status: VALIDATED

    Source sequence(s)
    CAAA01070179
    UniProtKB/Swiss-Prot
    P05713, P63011, Q3TSL4
    UniProtKB/TrEMBL
    Q0PD63
    Conserved Domains (1) summary
    cd01865
    Location:22186
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
  4. NM_001378893.1NP_001365822.1  ras-related protein Rab-3A

    Status: VALIDATED

    Source sequence(s)
    CAAA01070179
    UniProtKB/Swiss-Prot
    P05713, P63011, Q3TSL4
    UniProtKB/TrEMBL
    Q0PD63
    Conserved Domains (1) summary
    cd01865
    Location:22186
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
  5. NM_009001.7NP_033027.1  ras-related protein Rab-3A

    See identical proteins and their annotated locations for NP_033027.1

    Status: VALIDATED

    Source sequence(s)
    CAAA01070179
    Consensus CDS
    CCDS22379.1
    UniProtKB/Swiss-Prot
    P05713, P63011, Q3TSL4
    UniProtKB/TrEMBL
    Q0PD63
    Related
    ENSMUSP00000034301.6, ENSMUST00000034301.12
    Conserved Domains (1) summary
    cd01865
    Location:22186
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71207258..71211276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153836.1XP_036009729.1  ras-related protein Rab-3A isoform X1

    UniProtKB/Swiss-Prot
    P05713, P63011, Q3TSL4
    UniProtKB/TrEMBL
    Q0PD63
    Conserved Domains (1) summary
    cd01865
    Location:22186
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D