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RAB2A RAB2A, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 5862, updated on 8-Jul-2021

Summary

Official Symbol
RAB2Aprovided by HGNC
Official Full Name
RAB2A, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9763
See related
Ensembl:ENSG00000104388 MIM:179509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LHX; RAB2
Summary
The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in brain (RPKM 44.0), thyroid (RPKM 43.9) and 25 other tissues See more
Orthologs
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Genomic context

See RAB2A in Genome Data Viewer
Location:
8q12.1-q12.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (60516910..60623644)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (61429469..61536203)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene PDCL3 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1301 Neighboring gene chromodomain helicase DNA binding protein 7 Neighboring gene IFITM3 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RAB2A, member RAS oncogene family (RAB2A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in lysosomal membrane HDA PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
ras-related protein Rab-2A
Names
RAB2, member RAS oncogene family
small GTP binding protein RAB2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242644.1NP_001229573.1  ras-related protein Rab-2A isoform b

    See identical proteins and their annotated locations for NP_001229573.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. This results in a shorter isoform (b) missing an internal protein segment compared to isoform a.
    Source sequence(s)
    AC068389, AK297576, AW301641, DA648682
    Consensus CDS
    CCDS56537.1
    UniProtKB/Swiss-Prot
    P61019
    Related
    ENSP00000431846.1, ENST00000531289.5
    Conserved Domains (1) summary
    PLN03108
    Location:1164
    PLN03108; Rab family protein; Provisional
  2. NM_002865.3NP_002856.1  ras-related protein Rab-2A isoform a

    See identical proteins and their annotated locations for NP_002856.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC068389, AW301641, DA648682, X12953
    Consensus CDS
    CCDS6175.1
    UniProtKB/Swiss-Prot
    P61019
    UniProtKB/TrEMBL
    A0A024R7V6
    Related
    ENSP00000262646.7, ENST00000262646.12
    Conserved Domains (1) summary
    PLN03108
    Location:1188
    PLN03108; Rab family protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    60516910..60623644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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