Rab2a RAB2A, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab2aprovided by MGI
Official Full Name: RAB2A, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:1928750
See related: Ensembl:ENSMUSG00000047187 AllianceGenome:MGI:1928750
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rab2; 9330148M11Rik
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Golgi organization. Predicted to act upstream of or within intracellular protein transport. Located in Golgi apparatus. Is expressed in dorsal root ganglion; eye; foregut; limb; and limb mesenchyme. Orthologous to human RAB2A (RAB2A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 79.3), adrenal adult (RPKM 75.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 A1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (8535178..8607702)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (8535469..8607702)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that the dual effector, Noc2, regulates the transition from Rab2a-mediated granule biogenesis to Rab27a-mediated granule exocytosis.
Title: Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2.
Symbiotic bacteria directed selective cargo sorting in Paneth cells to promote symbiosis through Nod2 and LRRK2. Deficiency of Nod2, LRRK2 or Rab2a or depletion of commensals resulted in lysosomal degradation of lysozyme.
Title: Commensal bacteria direct selective cargo sorting to promote symbiosis.
Rab2A is a pivotal switch protein that promotes either secretion or endoplasmic reticulum-associated degradation of (pro)insulin in insulin-secreting cells.
Title: Rab2A is a pivotal switch protein that promotes either secretion or ER-associated degradation of (pro)insulin in insulin-secreting cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rab2a (e-PCR), detects polymorphism
- UniSTS:515979

RH126830 (e-PCR)
- UniSTS:207594

Homology

Homologs of the Rab2a gene: The Rab2a gene is conserved in human, chimpanzee, Rhesus monkey, dog, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 479 organisms have orthologs with human gene Rab2a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular protein transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-2A

Names: GTP-binding protein; RAB2, member RAS oncogene family

NP_067493.1

EC 3.6.5.2

XP_006538189.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411827.1 → NP_001398756.1 ras-related protein Rab-2A isoform 2

Status: VALIDATED

Source sequence(s)

AL732627, AL806521
NM_001411828.1 → NP_001398757.1 ras-related protein Rab-2A isoform 3

Status: VALIDATED

Source sequence(s)

AL732627, AL806521
NM_021518.4 → NP_067493.1 ras-related protein Rab-2A isoform 1

See identical proteins and their annotated locations for NP_067493.1

Status: VALIDATED

Source sequence(s)

AL732627, AL806521

Consensus CDS

CCDS17955.1

UniProtKB/Swiss-Prot

P53994, Q3UK45

UniProtKB/TrEMBL

A0A6P5PQR6, A0A8C6I4Q9, Q0PD65

Related

ENSMUSP00000057664.8, ENSMUST00000060232.8

Conserved Domains (1) summary

cl27030
Location:1 → 212

Ras; Ras family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

8535178..8607702

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538126.5 → XP_006538189.1 ras-related protein Rab-2A isoform X1

Conserved Domains (1) summary

cd01866
Location:3 → 158

Rab2; Rab GTPase family 2 (Rab2)