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SRPRB SRP receptor subunit beta [ Homo sapiens (human) ]

Gene ID: 58477, updated on 6-Nov-2022

Summary

Official Symbol
SRPRBprovided by HGNC
Official Full Name
SRP receptor subunit betaprovided by HGNC
Primary source
HGNC:HGNC:24085
See related
Ensembl:ENSG00000144867 MIM:616883; AllianceGenome:HGNC:24085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APMCF1; SR-beta
Summary
The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 18.4), testis (RPKM 17.1) and 25 other tissues See more
Orthologs
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Genomic context

See SRPRB in Genome Data Viewer
Location:
3q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (133784023..133828574)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (136529221..136573768)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (133502867..133547418)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transferrin Neighboring gene RNA, 5S ribosomal pseudogene 140 Neighboring gene uncharacterized LOC105374116 Neighboring gene ACSL3 pseudogene 1 Neighboring gene RAB6B, member RAS oncogene family Neighboring gene Sharpr-MPRA regulatory region 14374 Neighboring gene chromosome 3 putative open reading frame 36 Neighboring gene solute carrier organic anion transporter family member 2A1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies two loci strongly affecting transferrin glycosylation.
EBI GWAS Catalog
Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify signal recognition particle receptor B subunit (SRPRB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify signal recognition particle receptor B subunit (SRPRB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify signal recognition particle receptor B subunit (SRPRB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify signal recognition particle receptor B subunit (SRPRB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of signal recognition particle receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of signal recognition particle receptor complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
signal recognition particle receptor subunit beta
Names
SRP receptor beta subunit
signal recognition particle receptor, B subunit
signal recognition particle receptor, beta subunit

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379313.1NP_001366242.1  signal recognition particle receptor subunit beta

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC080128
    Consensus CDS
    CCDS3081.1
    UniProtKB/Swiss-Prot
    Q8N2D8
    UniProtKB/TrEMBL
    D3DND2
    Related
    ENSP00000503923.1, ENST00000678299.1
    Conserved Domains (1) summary
    pfam09439
    Location:62241
    SRPRB; Signal recognition particle receptor beta subunit
  2. NM_021203.4NP_067026.3  signal recognition particle receptor subunit beta

    See identical proteins and their annotated locations for NP_067026.3

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC080128
    Consensus CDS
    CCDS3081.1
    UniProtKB/Swiss-Prot
    Q8N2D8, Q9Y5M8
    UniProtKB/TrEMBL
    D3DND2, Q549N5
    Related
    ENSP00000418401.1, ENST00000466490.7
    Conserved Domains (1) summary
    pfam09439
    Location:62241
    SRPRB; Signal recognition particle receptor beta subunit

RNA

  1. NR_163491.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC080128

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    133784023..133828574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    136529221..136573768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)