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PURA purine rich element binding protein A [ Homo sapiens (human) ]

Gene ID: 5813, updated on 5-Sep-2021

Summary

Official Symbol
PURAprovided by HGNC
Official Full Name
purine rich element binding protein Aprovided by HGNC
Primary source
HGNC:HGNC:9701
See related
Ensembl:ENSG00000185129 MIM:600473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PUR1; MRD31; PURALPHA; PUR-ALPHA
Summary
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See PURA in Genome Data Viewer
Location:
5q31.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (140114109..140125619)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139493694..139505204)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene neuregulin 2 Neighboring gene mitosis associated long intergenic non-coding RNA 1 Neighboring gene uncharacterized LOC101929719 Neighboring gene IgA inducing protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2017-06-07)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2017-06-07)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of purine-rich element binding protein A (PURA) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev The interaction of Puralpha with HIV-1 RRE RNA occurs in the cytoplasm and enhances the association of HIV-1 Rev with the RRE PubMed
rev HIV-1 Rev and PURA colocalize in the perinuclear compartment. The 18-50 amino-acid residues of Rev interact with the region of amino acids 73-123 in PURA PubMed
Tat tat HIV-1 Tat proteins from different clades modulate differently Pur-alpha and SMAD4 to bind the JCV non-coding control region and affect differently on SMAD4 localization to the nucleus PubMed
tat Puralpha interacts with HIV-1 Tat to regulate the effect of Tat transactivating the HIV-1 LTR promoter, as well as the JCV promoter and other cellular promoters PubMed
tat Puralpha self-associates in an RNA dependent manner, an effect that is inhibited by HIV-1 Tat PubMed
tat Puralpha-mediated inhibition of protein translation can be inhibited by HIV-1 Tat PubMed
tat HIV-1 Tat cooperates with Puralpha, cyclin T1, and CDK9 to activate the TNFalpha promoter and upregulate TNFalpha expression PubMed
tat Expression of HIV-1 Tat in human SK-N-MC cells inhibits the NGF-signaling pathway leading to suppression of MAPK and reduction of Puralpha binding to the Egr-1 promoter PubMed
tat Binding of HIV-1 Tat to Puralpha is mediated through amino acids 49-72 of Tat and 100-121 of Puralpha, and is enhanced by RNA PubMed
tat HIV-1 Tat downregulates the expression of p35, a neuron-specific activator of cdk5, and also binds to Puralpha, which associates with cdk5, leading to deregulation of neuronal differentiation and survival PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in chromosome, telomeric region IC
Inferred by Curator
more info
PubMed 
located_in dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcriptional activator protein Pur-alpha
Names
purine-rich single-stranded DNA-binding protein alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041813.1 RefSeqGene

    Range
    5001..10294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005859.5NP_005850.1  transcriptional activator protein Pur-alpha

    See identical proteins and their annotated locations for NP_005850.1

    Status: REVIEWED

    Source sequence(s)
    AC011379, CK819077, M96684
    Consensus CDS
    CCDS4220.1
    UniProtKB/Swiss-Prot
    Q00577
    Related
    ENSP00000332706.3, ENST00000331327.5
    Conserved Domains (1) summary
    pfam04845
    Location:58278
    PurA; PurA ssDNA and RNA-binding protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    140114109..140125619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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