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Pura purine rich element binding protein A [ Mus musculus (house mouse) ]

Gene ID: 19290, updated on 9-Mar-2023

Summary

Official Symbol
Puraprovided by MGI
Official Full Name
purine rich element binding protein Aprovided by MGI
Primary source
MGI:MGI:103079
See related
Ensembl:ENSMUSG00000043991 AllianceGenome:MGI:103079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAGER-1; ssCRE-BP; Pur-alpha; 6330411E07Rik
Summary
Enables several functions, including SMAD binding activity; nucleic acid binding activity; and transcription regulator inhibitor activity. Involved in dendritic transport of messenger ribonucleoprotein complex; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including epithelial cell proliferation; lymphocyte proliferation; and positive regulation of cell population proliferation. Located in several cellular components, including dendrite; neuronal cell body; and nucleus. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and nervous system. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 31. Orthologous to human PURA (purine rich element binding protein A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 6.9), adrenal adult (RPKM 5.8) and 28 other tissues See more
Orthologs
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Genomic context

See Pura in Genome Data Viewer
Location:
18; 18 B2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36413614..36434575)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36280560..36292535)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene neuregulin 2 Neighboring gene RIKEN cDNA 4930471G03 gene Neighboring gene predicted gene, 41695 Neighboring gene IgA inducing protein Neighboring gene predicted gene, 41696 Neighboring gene cysteine-rich transmembrane module containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SMAD binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA regulatory element binding translation repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables purine-rich negative regulatory element binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables purine-rich negative regulatory element binding IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription regulator inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic transport of messenger ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dendritic transport of messenger ribonucleoprotein complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic transport of messenger ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IPI
Inferred from Physical Interaction
more info
PubMed 
located_in dendrite cytoplasm IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcriptional activator protein Pur-alpha
Names
purine-rich single-stranded DNA-binding protein alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008989.4NP_033015.1  transcriptional activator protein Pur-alpha

    See identical proteins and their annotated locations for NP_033015.1

    Status: VALIDATED

    Source sequence(s)
    AC131191
    Consensus CDS
    CCDS29151.1
    UniProtKB/Swiss-Prot
    P42669
    UniProtKB/TrEMBL
    A0A6P5P2V5, A0A8C6IDZ1
    Related
    ENSMUSP00000059404.4, ENSMUST00000051301.6
    Conserved Domains (1) summary
    pfam04845
    Location:57277
    PurA; PurA ssDNA and RNA-binding protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36413614..36434575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525724.5XP_006525787.1  transcriptional activator protein Pur-alpha isoform X1

    See identical proteins and their annotated locations for XP_006525787.1

    UniProtKB/Swiss-Prot
    P42669
    UniProtKB/TrEMBL
    A0A6P5P2V5, A0A8C6IDZ1
    Conserved Domains (1) summary
    pfam04845
    Location:57277
    PurA; PurA ssDNA and RNA-binding protein
  2. XM_011246860.4XP_011245162.1  transcriptional activator protein Pur-alpha isoform X1

    See identical proteins and their annotated locations for XP_011245162.1

    UniProtKB/Swiss-Prot
    P42669
    UniProtKB/TrEMBL
    A0A6P5P2V5, A0A8C6IDZ1
    Conserved Domains (1) summary
    pfam04845
    Location:57277
    PurA; PurA ssDNA and RNA-binding protein