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cdc25b cell division cycle 25B [ Danio rerio (zebrafish) ]

Gene ID: 57925, updated on 27-Mar-2024

Summary

Official Symbol
cdc25bprovided by ZNC
Official Full Name
cell division cycle 25Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-000330-5
See related
Ensembl:ENSDARG00000010792 AllianceGenome:ZFIN:ZDB-GENE-000330-5
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cdc25; cdc25A; sb:cb317
Summary
Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within positive regulation of mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle; and regulation of mitotic cell cycle, embryonic. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including DEL; anterior neural keel; axis; nervous system; and optic vesicle. Human ortholog(s) of this gene implicated in autosomal recessive polycystic kidney disease; cervical cancer; endometrial cancer; prostate cancer; and urinary bladder cancer. Orthologous to several human genes including CDC25B (cell division cycle 25B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See cdc25b in Genome Data Viewer
Location:
chromosome: 13
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (14915332..14929161, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (14784340..14798169, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene GDNF family receptor alpha 4a Neighboring gene adaptor related protein complex 5 subunit sigma 1 Neighboring gene notochord homeobox Neighboring gene empty spiracles homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
M-phase inducer phosphatase 2
Names
cell division cycle 25 homolog
sds
standstill
NP_001108567.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115095.2NP_001108567.1  M-phase inducer phosphatase 2

    Status: VALIDATED

    Source sequence(s)
    CN014310, CT625637, CT708651, EH500454, EU921896, FP128795
    UniProtKB/TrEMBL
    A0A8N7UYT2, B5LY73, B8A5N7
    Related
    ENSDARP00000003494.6, ENSDART00000020576.9
    Conserved Domains (2) summary
    cd01530
    Location:395514
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:104366
    M-inducer_phosp; M-phase inducer phosphatase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    14915332..14929161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)