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Cdon cell adhesion molecule-related/down-regulated by oncogenes [ Mus musculus (house mouse) ]

Gene ID: 57810, updated on 21-Apr-2024

Summary

Official Symbol
Cdonprovided by MGI
Official Full Name
cell adhesion molecule-related/down-regulated by oncogenesprovided by MGI
Primary source
MGI:MGI:1926387
See related
Ensembl:ENSMUSG00000038119 AllianceGenome:MGI:1926387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDO; Cd0; Orcam
Summary
Acts upstream of or within several processes, including animal organ development; positive regulation of intracellular signal transduction; and positive regulation of nitrogen compound metabolic process. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; limb bud; and sensory organ. Used to study holoprosencephaly 11. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Orthologous to human CDON (cell adhesion associated, oncogene regulated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 17.8), CNS E14 (RPKM 6.4) and 16 other tissues See more
Orthologs
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Genomic context

Location:
9 A4; 9 20.24 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35332836..35418948)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35421528..35507652)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33838 Neighboring gene predicted gene, 33974 Neighboring gene STARR-seq mESC enhancer starr_23768 Neighboring gene predicted gene, 25630 Neighboring gene V-set and immunoglobulin domain containing 10 like 2 Neighboring gene STARR-positive B cell enhancer ABC_E11404 Neighboring gene DEAD box helicase 25

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC129383

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell fate specification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell adhesion TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic body morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myoblast fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myoblast differentiation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of small GTPase mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of striated muscle tissue development ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within skeletal muscle satellite cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within striated muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
cell adhesion molecule-related/down-regulated by oncogenes
Names
CAM-related/down-regulated by oncogenes
immunoglobulin superfamily member CDO
oncogene-regulated cell adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405246.1NP_001392175.1  cell adhesion molecule-related/down-regulated by oncogenes precursor

    Status: VALIDATED

    Source sequence(s)
    AC118232, AC159894
    UniProtKB/Swiss-Prot
    E9QKV9, O88971, Q32MD9
  2. NM_001405247.1NP_001392176.1  cell adhesion molecule-related/down-regulated by oncogenes precursor

    Status: VALIDATED

    Source sequence(s)
    AC118232, AC159894
    UniProtKB/Swiss-Prot
    E9QKV9, O88971, Q32MD9
  3. NM_001405248.1NP_001392177.1  cell adhesion molecule-related/down-regulated by oncogenes precursor

    Status: VALIDATED

    Source sequence(s)
    AC118232, AC159894
    UniProtKB/Swiss-Prot
    E9QKV9, O88971, Q32MD9
  4. NM_001405249.1NP_001392178.1  cell adhesion molecule-related/down-regulated by oncogenes precursor

    Status: VALIDATED

    Source sequence(s)
    AC118232, AC159894
    UniProtKB/Swiss-Prot
    E9QKV9, O88971, Q32MD9
  5. NM_001405250.1NP_001392179.1  cell adhesion molecule-related/down-regulated by oncogenes precursor

    Status: VALIDATED

    Source sequence(s)
    AC118232, AC159894
    UniProtKB/Swiss-Prot
    E9QKV9, O88971, Q32MD9
  6. NM_001405251.1NP_001392180.1  cell adhesion molecule-related/down-regulated by oncogenes precursor

    Status: VALIDATED

    Source sequence(s)
    AC118232, AC159894
    UniProtKB/Swiss-Prot
    E9QKV9, O88971, Q32MD9
    Related
    ENSMUSP00000045547.6, ENSMUST00000042842.6
  7. NM_021339.3NP_067314.2  cell adhesion molecule-related/down-regulated by oncogenes precursor

    See identical proteins and their annotated locations for NP_067314.2

    Status: VALIDATED

    Source sequence(s)
    AC118232, AC159894
    Consensus CDS
    CCDS22964.1
    UniProtKB/Swiss-Prot
    E9QKV9, O88971, Q32MD9
    Related
    ENSMUSP00000113977.2, ENSMUST00000119129.10
    Conserved Domains (6) summary
    smart00408
    Location:236296
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:717807
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594662
    fn3; Fibronectin type III domain
    pfam07679
    Location:404516
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:2831
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28113
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    35332836..35418948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155157.1XP_036011050.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    UniProtKB/Swiss-Prot
    E9QKV9, O88971, Q32MD9
    Conserved Domains (6) summary
    smart00408
    Location:236296
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:717807
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594662
    fn3; Fibronectin type III domain
    pfam07679
    Location:404516
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:2831
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28113
    Ig; Immunoglobulin domain
  2. XM_006510512.5XP_006510575.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X2

    Conserved Domains (5) summary
    smart00408
    Location:325386
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:717807
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594662
    fn3; Fibronectin type III domain
    pfam07679
    Location:404516
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:33113
    Ig; Immunoglobulin domain
  3. XM_006510514.5XP_006510577.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X3

    UniProtKB/TrEMBL
    Q3TZM7
    Conserved Domains (5) summary
    smart00408
    Location:236296
    IGc2; Immunoglobulin C-2 Type
    pfam00041
    Location:594662
    fn3; Fibronectin type III domain
    pfam07679
    Location:404516
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:2831
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28113
    Ig; Immunoglobulin domain
  4. XM_036155159.1XP_036011052.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X3

    UniProtKB/TrEMBL
    Q3TZM7
    Conserved Domains (5) summary
    smart00408
    Location:236296
    IGc2; Immunoglobulin C-2 Type
    pfam00041
    Location:594662
    fn3; Fibronectin type III domain
    pfam07679
    Location:404516
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:2831
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28113
    Ig; Immunoglobulin domain
  5. XM_036155158.1XP_036011051.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X3

    UniProtKB/TrEMBL
    Q3TZM7
    Conserved Domains (5) summary
    smart00408
    Location:236296
    IGc2; Immunoglobulin C-2 Type
    pfam00041
    Location:594662
    fn3; Fibronectin type III domain
    pfam07679
    Location:404516
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:2831
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28113
    Ig; Immunoglobulin domain
  6. XM_036155161.1XP_036011054.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X3

    UniProtKB/TrEMBL
    Q3TZM7
    Conserved Domains (5) summary
    smart00408
    Location:236296
    IGc2; Immunoglobulin C-2 Type
    pfam00041
    Location:594662
    fn3; Fibronectin type III domain
    pfam07679
    Location:404516
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:2831
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28113
    Ig; Immunoglobulin domain
  7. XM_036155162.1XP_036011055.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X3

    UniProtKB/TrEMBL
    Q3TZM7
    Conserved Domains (5) summary
    smart00408
    Location:236296
    IGc2; Immunoglobulin C-2 Type
    pfam00041
    Location:594662
    fn3; Fibronectin type III domain
    pfam07679
    Location:404516
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:2831
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28113
    Ig; Immunoglobulin domain
  8. XM_036155160.1XP_036011053.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X3

    UniProtKB/TrEMBL
    Q3TZM7
    Related
    ENSMUSP00000117499.2, ENSMUST00000154652.8
    Conserved Domains (5) summary
    smart00408
    Location:236296
    IGc2; Immunoglobulin C-2 Type
    pfam00041
    Location:594662
    fn3; Fibronectin type III domain
    pfam07679
    Location:404516
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:2831
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28113
    Ig; Immunoglobulin domain
  9. XM_036155154.1XP_036011047.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    UniProtKB/Swiss-Prot
    E9QKV9, O88971, Q32MD9
    Conserved Domains (6) summary
    smart00408
    Location:236296
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:717807
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594662
    fn3; Fibronectin type III domain
    pfam07679
    Location:404516
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:2831
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28113
    Ig; Immunoglobulin domain
  10. XM_036155156.1XP_036011049.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    UniProtKB/Swiss-Prot
    E9QKV9, O88971, Q32MD9
    Conserved Domains (6) summary
    smart00408
    Location:236296
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:717807
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594662
    fn3; Fibronectin type III domain
    pfam07679
    Location:404516
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:2831
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28113
    Ig; Immunoglobulin domain
  11. XM_036155155.1XP_036011048.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    UniProtKB/Swiss-Prot
    E9QKV9, O88971, Q32MD9
    Conserved Domains (6) summary
    smart00408
    Location:236296
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:717807
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:594662
    fn3; Fibronectin type III domain
    pfam07679
    Location:404516
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:2831
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28113
    Ig; Immunoglobulin domain

RNA

  1. XR_004935506.1 RNA Sequence

  2. XR_004935503.1 RNA Sequence

  3. XR_004935507.1 RNA Sequence

  4. XR_004935504.1 RNA Sequence

  5. XR_004935505.1 RNA Sequence