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CDON cell adhesion associated, oncogene regulated [ Homo sapiens (human) ]

Gene ID: 50937, updated on 1-Jun-2020

Summary

Official Symbol
CDONprovided by HGNC
Official Full Name
cell adhesion associated, oncogene regulatedprovided by HGNC
Primary source
HGNC:HGNC:17104
See related
Ensembl:ENSG00000064309 MIM:608707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDO; CDON1; HPE11; ORCAM
Summary
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
Expression
Broad expression in thyroid (RPKM 12.5), ovary (RPKM 11.8) and 17 other tissues See more
Orthologs

Genomic context

See CDON in Genome Data Viewer
Location:
11q24.2
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (125956813..126063335, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (125826713..125933187, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 25 Neighboring gene V-set and immunoglobulin domain containing 10 like 2 Neighboring gene VISTA enhancer hs1641 Neighboring gene nucleosome assembly protein 1 like 1 pseudogene 1 Neighboring gene uncharacterized LOC107984407

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Holoprosencephaly 11
MedGen: C3280215 OMIM: 614226 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genetic variants associated with breast size also influence breast cancer risk.
NHGRI GWA Catalog
Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.
NHGRI GWA Catalog
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell fate specification IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
embryonic body morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic retina morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
lens development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of muscle cell differentiation TAS
Traceable Author Statement
more info
 
positive regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle satellite cell differentiation IEA
Inferred from Electronic Annotation
more info
 
smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with collagen-containing extracellular matrix TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cell adhesion molecule-related/down-regulated by oncogenes
Names
Cdon homolog
surface glycoprotein, Ig superfamily member

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029776.1 RefSeqGene

    Range
    5001..111475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243597.2NP_001230526.1  cell adhesion molecule-related/down-regulated by oncogenes isoform 1 precursor

    See identical proteins and their annotated locations for NP_001230526.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB209396, AP000842, BC098583, BC112362
    Consensus CDS
    CCDS58192.1
    UniProtKB/Swiss-Prot
    Q4KMG0
    Related
    ENSP00000376458.3, ENST00000392693.7
    Conserved Domains (6) summary
    cd00096
    Location:422514
    Ig; Immunoglobulin domain
    smart00408
    Location:326387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319397
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30115
    Ig; Immunoglobulin domain
  2. NM_001378964.1NP_001365893.1  cell adhesion molecule-related/down-regulated by oncogenes isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000821, AP000842
  3. NM_016952.5NP_058648.4  cell adhesion molecule-related/down-regulated by oncogenes isoform 2 precursor

    See identical proteins and their annotated locations for NP_058648.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AF004841, AI190027, AP000842, BC112362
    Consensus CDS
    CCDS8468.1
    UniProtKB/Swiss-Prot
    Q4KMG0
    Related
    ENSP00000263577.7, ENST00000263577.11
    Conserved Domains (6) summary
    cd00096
    Location:422514
    Ig; Immunoglobulin domain
    smart00408
    Location:326387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319397
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30115
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    125956813..126063335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017873.1XP_016873362.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    UniProtKB/Swiss-Prot
    Q4KMG0
    Conserved Domains (6) summary
    cd00096
    Location:422514
    Ig; Immunoglobulin domain
    smart00408
    Location:326387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319397
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30115
    Ig; Immunoglobulin domain
  2. XM_011542862.3XP_011541164.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    See identical proteins and their annotated locations for XP_011541164.1

    UniProtKB/Swiss-Prot
    Q4KMG0
    Conserved Domains (6) summary
    cd00096
    Location:422514
    Ig; Immunoglobulin domain
    smart00408
    Location:326387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319397
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30115
    Ig; Immunoglobulin domain
  3. XM_011542864.2XP_011541166.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    See identical proteins and their annotated locations for XP_011541166.1

    UniProtKB/Swiss-Prot
    Q4KMG0
    Conserved Domains (6) summary
    cd00096
    Location:422514
    Ig; Immunoglobulin domain
    smart00408
    Location:326387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319397
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30115
    Ig; Immunoglobulin domain
  4. XM_011542865.2XP_011541167.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    See identical proteins and their annotated locations for XP_011541167.1

    UniProtKB/Swiss-Prot
    Q4KMG0
    Conserved Domains (6) summary
    cd00096
    Location:422514
    Ig; Immunoglobulin domain
    smart00408
    Location:326387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319397
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30115
    Ig; Immunoglobulin domain
  5. XM_011542863.2XP_011541165.1  cell adhesion molecule-related/down-regulated by oncogenes isoform X1

    See identical proteins and their annotated locations for XP_011541165.1

    UniProtKB/Swiss-Prot
    Q4KMG0
    Conserved Domains (6) summary
    cd00096
    Location:422514
    Ig; Immunoglobulin domain
    smart00408
    Location:326387
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319397
    IG_like; Immunoglobulin like
    cd00063
    Location:721811
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:405517
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:30115
    Ig; Immunoglobulin domain

RNA

  1. XR_001747899.2 RNA Sequence

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