U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PTPN11 protein tyrosine phosphatase non-receptor type 11 [ Homo sapiens (human) ]

Gene ID: 5781, updated on 12-Jun-2025
Official Symbol
PTPN11provided by HGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 11provided by HGNC
Primary source
HGNC:HGNC:9644
See related
Ensembl:ENSG00000179295 MIM:176876; AllianceGenome:HGNC:9644
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CFC; NS1; JMML; SHP2; BPTP3; PTP2C; METCDS; PTP-1D; SH-PTP2; SH-PTP3
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in brain (RPKM 42.2), fat (RPKM 37.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See PTPN11 in Genome Data Viewer
Location:
12q24.13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (112418947..112509918)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (112395849..112486820)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112856751..112947722)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112818193-112818693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4883 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:112819879-112820378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7049 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112855308-112855956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112855957-112856604 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:112856605-112857252 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:112876497-112876700 Neighboring gene uncharacterized LOC124903023 Neighboring gene uncharacterized LOC124903024 Neighboring gene ribosomal protein L6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112954684-112955184 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:113015949-113016468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113018366-113018890 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:113039985-113040713 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:113055106-113055606 Neighboring gene NANOG hESC enhancer GRCh37_chr12:113079622-113080142 Neighboring gene rabphilin 3A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113147969-113148469 Neighboring gene microRNA 1302-1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:113185662-113186162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113229645-113230186 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:113306366-113306564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7052 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24142 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24404 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24357 and experimental_24368 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24317/24320 and experimental_24338 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24298, experimental_24301 and experimental_24306 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24293 and experimental_24295 Neighboring gene Sharpr-MPRA regulatory region 3381 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24264 and experimental_24270 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24215 and experimental_24231 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24171 and experimental_24176 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24163 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24159 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_24146 and experimental_24152 Neighboring gene 2'-5'-oligoadenylate synthetase 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Associated conditions

Description Tests
Juvenile myelomonocytic leukemia
MedGen: C0349639 OMIM: 607785 GeneReviews: Not available
Compare labs
LEOPARD syndrome 1 Compare labs
Metachondromatosis
MedGen: C0410530 OMIM: 156250 GeneReviews: Not available
Compare labs
Noonan syndrome
MedGen: C0028326 GeneReviews: Noonan Syndrome
Compare labs
Noonan syndrome 1
MedGen: C4551602 OMIM: 163950 GeneReviews: Noonan Syndrome
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2020-09-08)

ClinGen Genome Curation PagePubMed
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2020-09-08)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
EBI GWAS Catalog
Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
EBI GWAS Catalog
Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot.
EBI GWAS Catalog
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
EBI GWAS Catalog
New gene functions in megakaryopoiesis and platelet formation.
EBI GWAS Catalog
Novel associations for hypothyroidism include known autoimmune risk loci.
EBI GWAS Catalog

Replication interactions

Interaction Pubs
Progressive HIV-1 infection is linked to upregulated CXCL8 (IL8), CXCR1, and PTPN11 (SHP2) expression in PBMC samples from HIV-1 infected children PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HCV-E2 and HIV-gp120 act collaboratively to trigger a specific set of downstream signaling pathways that include activation of p38 mitogen-activated protein (MAP) kinase and the tyrosine phosphatase, SHP2, in hepatocytes PubMed
Tat tat HIV-1 Tat C treated human brain microvascular endothelial cells result in downregulation and dissociation of VE-PTP and SHP2 from VE-cadherin PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC14433

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables insulin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables non-membrane spanning protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables non-membrane spanning protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables non-membrane spanning protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
 
enables peptide hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor complex adaptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in ERBB signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ERBB signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell costimulation IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell costimulation TAS
Traceable Author Statement
more info
 
involved_in atrioventricular canal development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axonogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to epidermal growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cellular response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar cortex formation IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in face morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in genitalia development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hormone metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intestinal epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within megakaryocyte development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within microvillus organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of cortisol secretion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of growth hormone secretion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neutrophil activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neutrophil activation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neutrophil activation involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within organ growth IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within platelet formation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of D-glucose import IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interferon-beta production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ossification ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of type I interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of type I interferon-mediated signaling pathway TAS
Traceable Author Statement
more info
 
acts_upstream_of signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IC
Inferred by Curator
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion HTP PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
Preferred Names
tyrosine-protein phosphatase non-receptor type 11
Names
SH2 domain-containing protein tyrosine phosphatase 2
protein-tyrosine phosphatase 1D
protein-tyrosine phosphatase 2C
NP_001317366.1
NP_001361554.1
NP_002825.3
NP_542168.1
XP_011536915.1
XP_054228694.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007459.1 RefSeqGene

    Range
    5001..96182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_614

mRNA and Protein(s)

  1. NM_001330437.2NP_001317366.1  tyrosine-protein phosphatase non-receptor type 11 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC004086, AC004216
    Consensus CDS
    CCDS81741.1
    UniProtKB/TrEMBL
    A0A3G1LBG2
    Related
    ENSP00000489597.1, ENST00000635625.1
    Conserved Domains (3) summary
    cd09931
    Location:111218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272528
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11
  2. NM_001374625.1NP_001361554.1  tyrosine-protein phosphatase non-receptor type 11 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC004086, AC004216
    UniProtKB/TrEMBL
    A0A3G1LBG2
    Conserved Domains (3) summary
    cd09931
    Location:110217
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5102
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:271523
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11
  3. NM_002834.5NP_002825.3  tyrosine-protein phosphatase non-receptor type 11 isoform 1

    See identical proteins and their annotated locations for NP_002825.3

    Status: REVIEWED

    Source sequence(s)
    AC004086, AC004216
    Consensus CDS
    CCDS9163.1
    UniProtKB/Swiss-Prot
    A8K1D9, Q06124, Q96HD7
    UniProtKB/TrEMBL
    A0A3G1LBG2
    Related
    ENSP00000340944.3, ENST00000351677.7
    Conserved Domains (3) summary
    cd09931
    Location:111218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272524
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11
  4. NM_080601.3NP_542168.1  tyrosine-protein phosphatase non-receptor type 11 isoform 2

    See identical proteins and their annotated locations for NP_542168.1

    Status: REVIEWED

    Source sequence(s)
    BC008692
    Consensus CDS
    CCDS58280.1
    UniProtKB/TrEMBL
    A0A8I5KVS6
    Related
    ENSP00000376376.1, ENST00000392597.5
    Conserved Domains (3) summary
    cd09931
    Location:111218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:246459
    PTPc; Protein tyrosine phosphatase, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    112418947..112509918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538613.3XP_011536915.1  tyrosine-protein phosphatase non-receptor type 11 isoform X1

    UniProtKB/TrEMBL
    A0A3G1LBG2
    Conserved Domains (3) summary
    cd09931
    Location:110217
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5102
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:271527
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    112395849..112486820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372719.1XP_054228694.1  tyrosine-protein phosphatase non-receptor type 11 isoform X1

    UniProtKB/TrEMBL
    A0A3G1LBG2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018508.1: Suppressed sequence

    Description
    NM_018508.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.