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Ptpn11 protein tyrosine phosphatase, non-receptor type 11 [ Mus musculus (house mouse) ]

Gene ID: 19247, updated on 19-Feb-2024

Summary

Official Symbol
Ptpn11provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 11provided by MGI
Primary source
MGI:MGI:99511
See related
Ensembl:ENSMUSG00000043733 AllianceGenome:MGI:99511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Syp; Shp2; PTP1D; PTP2C; SAP-2; SHP-2; SH-PTP2; SH-PTP3; 2700084A17Rik
Summary
Enables cell adhesion molecule binding activity; protein tyrosine phosphatase activity; and signaling receptor binding activity. Involved in negative regulation of chondrocyte differentiation; positive regulation of cytokine production; and positive regulation of ossification. Acts upstream of or within several processes, including cell surface receptor signaling pathway; myeloid cell differentiation; and regulation of hormone secretion. Predicted to be located in several cellular components, including mitochondrion; plasma membrane raft; and stress fiber. Predicted to be part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study several diseases, including Noonan syndrome 1; Noonan syndrome with multiple lentigines; hepatocellular adenoma; intrinsic cardiomyopathy (multiple); and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 24.0), genital fat pad adult (RPKM 23.7) and 28 other tissues See more
Orthologs
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Genomic context

See Ptpn11 in Genome Data Viewer
Location:
5 61.72 cM; 5 F
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121268596..121329460, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121130533..121191397, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase 1 pseudogene Neighboring gene 2'-5' oligoadenylate synthetase 1D Neighboring gene predicted gene, 32185 Neighboring gene rabphilin 3A Neighboring gene STARR-positive B cell enhancer ABC_E3611 Neighboring gene STARR-positive B cell enhancer ABC_E4783 Neighboring gene STARR-positive B cell enhancer ABC_E6372 Neighboring gene STARR-seq mESC enhancer starr_14255 Neighboring gene STARR-positive B cell enhancer ABC_E4784 Neighboring gene predicted gene, 26205 Neighboring gene ribosomal protein L6 Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene STARR-positive B cell enhancer mm9_chr5:121780251-121780552 Neighboring gene predicted gene, 24671

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (19)  1 citation
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D1 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor substrate binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables non-membrane spanning protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables non-membrane spanning protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables non-membrane spanning protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor complex adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within Bergmann glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ERBB signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in atrioventricular canal development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebellar cortex formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cerebellar cortex formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in face morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in genitalia development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hormone-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inner ear development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intestinal epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within microvillus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organismal reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cortisol secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of growth hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within platelet formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in stress fiber ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 11
Names
SH2 domain-containing protein tyrosine phosphatase-2
protein-tyrosine phosphatase SYP
NP_001103462.1
NP_035332.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109992.1NP_001103462.1  tyrosine-protein phosphatase non-receptor type 11 isoform b

    See identical proteins and their annotated locations for NP_001103462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    AK159501, BC057398, BM899214, CF751511
    Consensus CDS
    CCDS51637.1
    UniProtKB/Swiss-Prot
    P35235, Q3TQ84, Q64509, Q6PCL5
    Related
    ENSMUSP00000098333.3, ENSMUST00000100770.9
    Conserved Domains (3) summary
    cd09931
    Location:111218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272524
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11
  2. NM_011202.3NP_035332.1  tyrosine-protein phosphatase non-receptor type 11 isoform a

    See identical proteins and their annotated locations for NP_035332.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK159501, BC057398, BM899214, CF751511
    Consensus CDS
    CCDS39247.1
    UniProtKB/Swiss-Prot
    P35235
    Related
    ENSMUSP00000058757.8, ENSMUST00000054547.9
    Conserved Domains (3) summary
    cd09931
    Location:111218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272528
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    121268596..121329460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)