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PTPN9 protein tyrosine phosphatase non-receptor type 9 [ Homo sapiens (human) ]

Gene ID: 5780, updated on 17-Jun-2019

Summary

Official Symbol
PTPN9provided by HGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 9provided by HGNC
Primary source
HGNC:HGNC:9661
See related
Ensembl:ENSG00000169410 MIM:600768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEG2; PTPMEG2
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 22.0), small intestine (RPKM 10.6) and 25 other tissues See more
Orthologs

Genomic context

See PTPN9 in Genome Data Viewer
Location:
15q24.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (75463251..75579315, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75759462..75871625, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 58 Neighboring gene mannosidase alpha class 2C member 1 Neighboring gene SIN3 transcription regulator family member A Neighboring gene ribosomal protein L13 pseudogene 4 Neighboring gene uncharacterized LOC105370902 Neighboring gene small nuclear ribonucleoprotein F-like Neighboring gene snurportin 1 Neighboring gene IMP U3 small nucleolar ribonucleoprotein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
NHGRI GWA Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies PTPN9/PTP-MEG2, a member of the protein tyrosine phosphatase family, is important for HIV-1 replication PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: SNUPN

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
non-membrane spanning protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection terminus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 9
Names
PTPase-MEG2
protein-tyrosine phosphatase MEG2
NP_002824.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002833.4NP_002824.1  tyrosine-protein phosphatase non-receptor type 9

    See identical proteins and their annotated locations for NP_002824.1

    Status: REVIEWED

    Source sequence(s)
    AC105036, AC105137, BC071574, M83738
    Consensus CDS
    CCDS10280.1
    UniProtKB/Swiss-Prot
    P43378
    UniProtKB/TrEMBL
    Q6IQ43
    Related
    ENSP00000482732.1, ENST00000618819.4
    Conserved Domains (3) summary
    smart00194
    Location:302573
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00516
    Location:90240
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    smart01100
    Location:2068
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    75463251..75579315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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