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Ptpn9 protein tyrosine phosphatase, non-receptor type 9 [ Mus musculus (house mouse) ]

Gene ID: 56294, updated on 8-Dec-2022

Summary

Official Symbol
Ptpn9provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 9provided by MGI
Primary source
MGI:MGI:1928376
See related
Ensembl:ENSMUSG00000032290 AllianceGenome:MGI:1928376
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MEG2
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to act upstream of or within negative regulation of neuron projection development; peptidyl-tyrosine dephosphorylation; and positive regulation of protein localization to plasma membrane. Located in neuron projection terminus. Is expressed in several structures, including genitourinary system; liver; lung; midbrain; and spleen. Orthologous to human PTPN9 (protein tyrosine phosphatase non-receptor type 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 23.8), limb E14.5 (RPKM 15.2) and 28 other tissues See more
Orthologs
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Genomic context

See Ptpn9 in Genome Data Viewer
Location:
9; 9 B
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56902252..56970092)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56994968..57062808)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene IMP3, U3 small nucleolar ribonucleoprotein Neighboring gene snurportin 1 Neighboring gene predicted gene 10658 Neighboring gene RIKEN cDNA 2700012I20 gene Neighboring gene transcriptional regulator, SIN3A (yeast) Neighboring gene mannosidase, alpha, class 2C, member 1, opposite strand Neighboring gene mannosidase, alpha, class 2C, member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 9
Names
PTPase MEG2
Protein-tyrosine phosphatase, non-receptor type 9 (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2)
protein-tyrosine phosphatase MEG2
NP_062625.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019651.2NP_062625.2  tyrosine-protein phosphatase non-receptor type 9

    See identical proteins and their annotated locations for NP_062625.2

    Status: PROVISIONAL

    Source sequence(s)
    BC053017
    Consensus CDS
    CCDS23215.1
    UniProtKB/Swiss-Prot
    O35239, Q7TSK0
    UniProtKB/TrEMBL
    Q2M4G8
    Related
    ENSMUSP00000034832.7, ENSMUST00000034832.8
    Conserved Domains (4) summary
    smart00194
    Location:302573
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00516
    Location:90240
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    smart01100
    Location:2066
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00047
    Location:329573
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    56902252..56970092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)